https://scholars.lib.ntu.edu.tw/handle/123456789/536972
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | JIA-FENG WU | en_US |
dc.contributor.author | Lee C.-H. | en_US |
dc.contributor.author | HUEY-LING CHEN | en_US |
dc.contributor.author | YEN-HSUAN NI | en_US |
dc.contributor.author | HONG-YUAN HSU | en_US |
dc.contributor.author | Sheu J.-C. | en_US |
dc.contributor.author | Tsuei D.-J. | en_US |
dc.contributor.author | MEI-HWEI CHANG | en_US |
dc.creator | Wu J.-F.;Lee C.-H.;Chen H.-L.;Ni Y.-H.;Hsu H.-Y.;Sheu J.-C.;Tsuei D.-J.;Mei-Hwei Chang | - |
dc.date.accessioned | 2021-01-04T07:33:41Z | - |
dc.date.available | 2021-01-04T07:33:41Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1936-0533 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84875271173&doi=10.1007%2fs12072-012-9350-y&partnerID=40&md5=a367c43604456dc2de61721d7bc5ac62 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/536972 | - |
dc.description.abstract | Purpose: Hepatoblastoma is a rare childhood liver malignancy with limited relevant cytogenetic data. This study aimed to discover common genomic copy-number variations (CNVs) in subjects with hepatobalstoma and its relevance to the clinical course. Methods: Gene copy-number was systemically rated by high-resolution comparative genomic hybridization (CGH) DNA oligonucleotide microarray. The study group consisted of 12 children (7 males and 5 females) with hepatoblastoma and another 20 healthy individuals (10 males and 10 females) as controls. The influence of recurrent CNVs on clinical outcomes was analyzed. Results: Four highly recurrent CNVs were identified in these 12 hepatoblastoma children after comparison with controls, including a gain on 1p13.3 (n = 3, 25%) and losses on 5p15.33 (n = 4, 33.3%), 16q12.2 (n = 4, 33.3%), and 19q13.42 (n = 3, 25%). The most prevalent sites of genomic deletion were 5p15.33 and 16q12.2. Zinc finger, DHHC-type containing 11 (ZDHHC11) and DHHC-type containing 11B (ZDHHC11B) were mapped to 5p15.33, which was associated with a lower rate of survival with native liver (p = 0.03). The carboxylesterase 4-like (CES4) gene that mapped to 16q12.2 was associated with smaller tumor size at presentation. Conclusions: Deletions of 5p15.33 (33.3%) and 16q12.2 (33.3%) are the most frequent hepatoblastoma-related events in our patient group with 5p15.33 microdeletion as a potential biomarker for the fate of survival with native liver. ? 2012 Asian Pacific Association for the Study of the Liver. | - |
dc.relation.ispartof | Hepatology International | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | carboxylesterase; cisplatin; DNA; doxorubicin; unclassified drug; zinc finger DHHC type containing 11 protein; zinc finger DHHC type containing 11B protein; zinc finger protein; adjuvant therapy; article; cancer mortality; cancer prognosis; cancer survival; carboxylesterase 4 like gene; child; chromosome 16q; chromosome 19q; chromosome 1p; chromosome 5p; chromosome deletion; chromosome loss; chromosome map; clinical article; clinical feature; comparative genomic hybridization; controlled study; copy number variation; disease association; DNA microarray; female; gene; gene deletion; gene dosage; hepatoblastoma; human; infant; liver resection; liver transplantation; male; nucleotide sequence; preschool child; priority journal; recurrence free survival; tumor volume | - |
dc.title | Copy-number variations in hepatoblastoma associate with unique clinical features | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1007/s12072-012-9350-y | - |
dc.identifier.scopus | 2-s2.0-84875271173 | - |
dc.relation.pages | 208-214 | - |
dc.relation.journalvolume | 7 | - |
dc.relation.journalissue | 1 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.orcid | 0000-0001-6343-1658 | - |
crisitem.author.orcid | 0000-0002-4074-5838 | - |
crisitem.author.orcid | 0000-0002-1158-5249 | - |
crisitem.author.orcid | 0000-0002-5720-4835 | - |
crisitem.author.orcid | 0000-0002-3648-9261 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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