https://scholars.lib.ntu.edu.tw/handle/123456789/536986
Title: | Effect of age on the incidence of acute hepatitis b after 25 years of a universal newborn hepatitis B immunization program in Taiwan | Authors: | Su W.-J. Liu C.-C. DING-PING LIU Chen S.-F. Huang J.-J. Chan T.-C. MEI-HWEI CHANG |
Issue Date: | 2012 | Journal Volume: | 205 | Journal Issue: | 5 | Start page/Pages: | 757-762 | Source: | Journal of Infectious Diseases | Abstract: | (See the editorial commentary by Schwarz, on page 702.)Background. Raising concerns about the waning immunity of cohorts receiving hepatitis B virus (HBV) vaccination in infancy persuaded us to identify the changing incidence of acute hepatitis B (AHB) in children and young adults.Methods.Data on AHB surveillance through the National Notifiable Disease Surveillance System from July 2001 to June 2009 were collected and described. Cases were divided into 2 cohorts according to their birth year: before or after the universal newborn HBV vaccination program. Age-specific incidence was compared for the 2 birth cohorts with diagnosis at age 15-24 years.Results.In total, 2226 patients with AHB were identified. AHB rates varied by age; the highest rates occurred among unvaccinated individuals aged 25-39 years (2.33/100000). Due to breakthrough HBV infection from mother-to-infant transmission, vaccinated infants (0.78/100000) had higher rates than those aged 1-14 years (0.04/100000), who had the lowest rates. The incidence in vaccinated birth cohorts was significantly lower than in unvaccinated birth cohorts among patients 15-24 years old, with an adjusted-relative risk of 0.42.Conclusions.Implementation of universal-at-birth HBV immunization programs has effectively reduced the occurrence of AHB among adolescents and young adults in Taiwan for >25 years, making infants and the 25-39-year-old cohort additional targets for preventing AHB. ? 2012 The Author. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863146656&doi=10.1093%2finfdis%2fjir852&partnerID=40&md5=1ccce01061883acef0bdbbaff7aeb2bc https://scholars.lib.ntu.edu.tw/handle/123456789/536986 |
ISSN: | 0022-1899 | DOI: | 10.1093/infdis/jir852 | SDG/Keyword: | hepatitis B vaccine; acute hepatitis; adolescent; adult; age; article; birth; child; cohort analysis; comparative study; controlled study; disease surveillance; hepatitis B; human; immunization; infant; infection rate; infection risk; major clinical study; morbidity; newborn care; outcome assessment; patient identification; priority journal; risk factor; Taiwan; vaccination; vertical transmission; Adolescent; Adult; Age Factors; Child; Child, Preschool; Cohort Studies; Hepatitis B; Humans; Incidence; Infant; Infant, Newborn; Poisson Distribution; Population Surveillance; Taiwan; Vaccination; Young Adult |
Appears in Collections: | 醫學系 |
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