https://scholars.lib.ntu.edu.tw/handle/123456789/536996
標題: | Long-term effect of maternal HBeAg on delayed HBeAg seroconversion in offspring with chronic hepatitis B infection | 作者: | Tseng Y.-R. JIA-FENG WU YEN-HSUAN NI HUEY-LING CHEN Chen C.-C. Wen W.-H. HONG-YUAN HSU MEI-HWEI CHANG |
公開日期: | 2011 | 卷: | 31 | 期: | 9 | 起(迄)頁: | 1373-1380 | 來源出版物: | Liver International | 摘要: | Background and aims: This cohort study investigated the long-term effect of maternal hepatitis B virus (HBV) sero-status on the spontaneous HBeAg seroconversion in offspring with chronic HBV infection. Methods: A total of 185 HBeAg-positive chronic HBV-infected children, with maternal HBV seromarkers checked, were enrolled. The median age at enrolment and follow-up duration was 5.7 years (range, neonate to 16.5 years) and 20.2 years (range, 4.2-31.0 years) respectively. These children were grouped according to the initial maternal HBsAg and HBeAg status: (i) children of non-carrier mothers (n=48); (ii) children of HBeAg-negative chronic HBV-infected mothers (n=57); (iii) children of HBeAg-positive chronic HBV-infected mothers (n=80). HBV seromarkers and liver function profiles of these children were performed at 6-month intervals. Results: One hundred and twenty-one (65.4%) subjects had achieved spontaneous HBeAg seroconversion at the end of this follow-up study. Spontaneous HBeAg seroconversion was achieved in 83.3% of children with non-carrier mothers, 73.7% of children with HBeAg-negative chronic HBV-infected mothers and 48.8% of children with HBeAg-positive mothers during similar duration (P<0.001). Positive maternal HBeAg and genotype C were associated with delayed spontaneous HBeAg seroconversion in multivariate analysis (P=0.01 and P=0.002 respectively). In children of HBeAg-positive chronic HBV-infected mothers, persistent presence of maternal HBeAg showed a trend of association with delayed HBeAg seroconversion in their offspring (P=0.06). Children of late maternal HBeAg seroconversion (>40 years old) had delayed HBeAg seroconversion compared with those of early HBeAg seroconversion mothers (P=0.06). Conclusions: Persistence of maternal HBeAg is an important risk factor for delayed spontaneous HBeAg seroconversion in children with chronic HBV infection. ? 2011 John Wiley & Sons A/S. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-80052526205&doi=10.1111%2fj.1478-3231.2011.02574.x&partnerID=40&md5=2f88b00e636420725457b0ddba2d42e2 https://scholars.lib.ntu.edu.tw/handle/123456789/536996 |
ISSN: | 1478-3223 | DOI: | 10.1111/j.1478-3231.2011.02574.x | SDG/關鍵字: | alanine aminotransferase; hepatitis B antigen; adolescent; adult; alanine aminotransferase blood level; article; child; female; follow up; genotype; hepatitis B; human; infant; major clinical study; male; mother child relation; newborn; seroconversion; Adolescent; Adult; Alanine Transaminase; Biological Markers; Carrier State; Chi-Square Distribution; Child; Child, Preschool; Female; Genotype; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Kaplan-Meier Estimate; Male; Maternal-Fetal Exchange; Middle Aged; Pregnancy; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; Sex Factors; Taiwan; Time Factors; Young Adult |
顯示於: | 醫學系 |
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