https://scholars.lib.ntu.edu.tw/handle/123456789/536996
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Tseng Y.-R. | en_US |
dc.contributor.author | JIA-FENG WU | en_US |
dc.contributor.author | YEN-HSUAN NI | en_US |
dc.contributor.author | HUEY-LING CHEN | en_US |
dc.contributor.author | Chen C.-C. | en_US |
dc.contributor.author | Wen W.-H. | en_US |
dc.contributor.author | HONG-YUAN HSU | en_US |
dc.contributor.author | MEI-HWEI CHANG | en_US |
dc.creator | Tseng Y.-R.;Wu J.-F.;Ni Y.-H.;Chen H.-L.;Chen C.-C.;Wen W.-H.;Hsu H.-Y.;Mei-Hwei Chang | - |
dc.date.accessioned | 2021-01-04T07:33:48Z | - |
dc.date.available | 2021-01-04T07:33:48Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1478-3223 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-80052526205&doi=10.1111%2fj.1478-3231.2011.02574.x&partnerID=40&md5=2f88b00e636420725457b0ddba2d42e2 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/536996 | - |
dc.description.abstract | Background and aims: This cohort study investigated the long-term effect of maternal hepatitis B virus (HBV) sero-status on the spontaneous HBeAg seroconversion in offspring with chronic HBV infection. Methods: A total of 185 HBeAg-positive chronic HBV-infected children, with maternal HBV seromarkers checked, were enrolled. The median age at enrolment and follow-up duration was 5.7 years (range, neonate to 16.5 years) and 20.2 years (range, 4.2-31.0 years) respectively. These children were grouped according to the initial maternal HBsAg and HBeAg status: (i) children of non-carrier mothers (n=48); (ii) children of HBeAg-negative chronic HBV-infected mothers (n=57); (iii) children of HBeAg-positive chronic HBV-infected mothers (n=80). HBV seromarkers and liver function profiles of these children were performed at 6-month intervals. Results: One hundred and twenty-one (65.4%) subjects had achieved spontaneous HBeAg seroconversion at the end of this follow-up study. Spontaneous HBeAg seroconversion was achieved in 83.3% of children with non-carrier mothers, 73.7% of children with HBeAg-negative chronic HBV-infected mothers and 48.8% of children with HBeAg-positive mothers during similar duration (P<0.001). Positive maternal HBeAg and genotype C were associated with delayed spontaneous HBeAg seroconversion in multivariate analysis (P=0.01 and P=0.002 respectively). In children of HBeAg-positive chronic HBV-infected mothers, persistent presence of maternal HBeAg showed a trend of association with delayed HBeAg seroconversion in their offspring (P=0.06). Children of late maternal HBeAg seroconversion (>40 years old) had delayed HBeAg seroconversion compared with those of early HBeAg seroconversion mothers (P=0.06). Conclusions: Persistence of maternal HBeAg is an important risk factor for delayed spontaneous HBeAg seroconversion in children with chronic HBV infection. ? 2011 John Wiley & Sons A/S. | - |
dc.relation.ispartof | Liver International | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | alanine aminotransferase; hepatitis B antigen; adolescent; adult; alanine aminotransferase blood level; article; child; female; follow up; genotype; hepatitis B; human; infant; major clinical study; male; mother child relation; newborn; seroconversion; Adolescent; Adult; Alanine Transaminase; Biological Markers; Carrier State; Chi-Square Distribution; Child; Child, Preschool; Female; Genotype; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Kaplan-Meier Estimate; Male; Maternal-Fetal Exchange; Middle Aged; Pregnancy; Proportional Hazards Models; Prospective Studies; Risk Assessment; Risk Factors; Sex Factors; Taiwan; Time Factors; Young Adult | - |
dc.title | Long-term effect of maternal HBeAg on delayed HBeAg seroconversion in offspring with chronic hepatitis B infection | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1111/j.1478-3231.2011.02574.x | - |
dc.identifier.pmid | 21745315 | - |
dc.identifier.scopus | 2-s2.0-80052526205 | - |
dc.relation.pages | 1373-1380 | - |
dc.relation.journalvolume | 31 | - |
dc.relation.journalissue | 9 | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.orcid | 0000-0001-6343-1658 | - |
crisitem.author.orcid | 0000-0002-1158-5249 | - |
crisitem.author.orcid | 0000-0002-4074-5838 | - |
crisitem.author.orcid | 0000-0002-5720-4835 | - |
crisitem.author.orcid | 0000-0002-3648-9261 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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