https://scholars.lib.ntu.edu.tw/handle/123456789/537007
標題: | Effects of the infant stool color card screening program on 5-year outcome of biliary Atresia in Taiwan | 作者: | Lien T.-H. MEI-HWEI CHANG JIA-FENG WU HUEY-LING CHEN Lee H.-C. Chen A.-C. Tiao M.-M. Wu T.-C. Yang Y.-J. Lin C.-C. Lai M.-W. HONG-YUAN HSU YEN-HSUAN NI |
公開日期: | 2011 | 卷: | 53 | 期: | 1 | 起(迄)頁: | 202-208 | 來源出版物: | Hepatology | 摘要: | In Taiwan, a screening system using an infant stool color card to promote the early diagnosis of biliary atresia (BA) was established in 2002. This study aimed to investigate the 5-year outcome of BA before and after using the screening program. BA patients were divided into three cohorts according to their birth dates. The patients in cohort A (n = 89) were born before the stool card screening program (1990-2000); those in cohort B (n = 28) were screened by the stool card regional screening program (2002-2003); and those in cohort C (n = 74) were screened by the stool card universal screening program (2004-2005). The relative odds ratios were computed using logistic regression to compare the different factors affecting survival time. The rate of age at Kasai operation <60 days was 49.4% and 65.7% in cohorts A and B+C, respectively (P = 0.02). The jaundice-free (total serum bilirubin <2.0 mg/dL) rate 3 months after surgery was 34.8% and 60.8% in cohorts A and B+C, respectively (P < 0.001). The 3-year jaundice-free survival rate with native liver was 31.5% in cohort A and 56.9% in cohort B+C (P < 0.001), whereas the 3-year overall survival rates were 64.0% and 89.2%, respectively (P < 0.001). The 5-year jaundice-free survival rate with native liver was 27.3% in cohort A and 64.3% in cohort B (P < 0.001), and the 5-year overall survival rates were 55.7% and 89.3%, respectively (P < 0.001). Conclusion: The stool color card screening program for BA allows for earlier Kasai operation, which increases the jaundice-free rate at 3 months postsurgery. With higher surgical success rates, the 3- and 5-year outcome of BA patients in Taiwan improves remarkably. ? 2010 American Association for the Study of Liver Diseases. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-78751505016&doi=10.1002%2fhep.24023&partnerID=40&md5=c7f8e9793415599838b9666ef9302386 https://scholars.lib.ntu.edu.tw/handle/123456789/537007 |
ISSN: | 0270-9139 | DOI: | 10.1002/hep.24023 | SDG/關鍵字: | bilirubin; article; bile duct atresia; bilirubin blood level; cohort analysis; color; disease free survival; feces analysis; female; human; infant; infant stool color card; jaundice; major clinical study; male; newborn; outcome assessment; overall survival; portoenterostomy; priority journal; risk assessment; screening; survival time; Taiwan; Biliary Atresia; Cohort Studies; Color; Disease-Free Survival; Feces; Female; Humans; Infant; Infant, Newborn; Male; Neonatal Screening; Portoenterostomy, Hepatic; Treatment Outcome |
顯示於: | 醫學系 |
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