https://scholars.lib.ntu.edu.tw/handle/123456789/537013
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chen C.-Y. | en_US |
dc.contributor.author | HONG-YUAN HSU | en_US |
dc.contributor.author | Liu C.-C. | en_US |
dc.contributor.author | MEI-HWEI CHANG | en_US |
dc.contributor.author | YEN-HSUAN NI | en_US |
dc.creator | Chen C.-Y.;Hsu H.-Y.;Liu C.-C.;Mei-Hwei Chang;Ni Y.-H. | - |
dc.date.accessioned | 2021-01-04T07:33:53Z | - |
dc.date.available | 2021-01-04T07:33:53Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0264-410X | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77955056692&doi=10.1016%2fj.vaccine.2010.06.029&partnerID=40&md5=d73d3b190e859a8d4551fd34b234508b | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/537013 | - |
dc.description.abstract | Background: This study is aimed to investigate if there was increased risk of HBV acquisition among first graders in Taiwan during a 3-year follow-up period. Methods: A total of 1545 healthy first graders, who were vaccinated against HBV in infancy, were recruited in 2005. All subjects were checked for hepatitis B surface antigens (HBsAg), antibodies to HBsAg (anti-HBs), and to the hepatitis B core antigen (anti-HBc). Nucleotide sequence of the " a" determinant of HBsAg was determined by polymerase chain reaction and direct sequencing in the HBsAg carriers. Results: Among 1545 subjects, 0.78% were HBsAg seropositive, 54.30% were anti-HBs seropositive, and 1.68% anti-HBc seropositive. Three of the 10 HBV carriers (30%), whose HBV DNA were sequenced for the S gene, had surface antigen mutants at the " a" determinant. Conclusion: There were no new chronic HBV infections in this cohort of children for two consecutive years. HBV S gene vaccine escape mutants did exist in the vaccine-failure population, but they may not have made a major health impact. ? 2010 Elsevier Ltd. | - |
dc.relation.ispartof | Vaccine | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | hepatitis B antibody; hepatitis B core antigen; hepatitis B surface antigen; virus DNA; hepatitis B antibody; hepatitis B core antigen; hepatitis B surface antigen; hepatitis B vaccine; virus DNA; article; cohort analysis; disease surveillance; DNA sequence; female; follow up; gene; hepatitis B; Hepatitis B virus; human; human experiment; immunization; male; normal human; nucleotide sequence; polymerase chain reaction; primary school; priority journal; questionnaire; risk factor; seroepidemiology; Taiwan; virus carrier; blood; child; genetics; hepatitis B; heterozygote; Carrier State; Child; DNA, Viral; Female; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Humans; Male; Seroepidemiologic Studies; Taiwan; Carrier State; Child; DNA, Viral; Female; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Humans; Male; Seroepidemiologic Studies; Taiwan | - |
dc.title | Stable seroepidemiology of hepatitis B after universal immunization in Taiwan: A 3-year study of national surveillance of primary school students | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.vaccine.2010.06.029 | - |
dc.identifier.pmid | 20598405 | - |
dc.identifier.scopus | 2-s2.0-77955056692 | - |
dc.relation.pages | 5605-5608 | - |
dc.relation.journalvolume | 28 | - |
dc.relation.journalissue | 34 | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.orcid | 0000-0002-5720-4835 | - |
crisitem.author.orcid | 0000-0002-3648-9261 | - |
crisitem.author.orcid | 0000-0002-1158-5249 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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