https://scholars.lib.ntu.edu.tw/handle/123456789/537041
標題: | Response to booster hepatitis B vaccines in liver-transplanted children primarily vaccinated in infancy | 作者: | YEN-HSUAN NI MING-CHIH HO JIA-FENG WU HUEY-LING CHEN YAO-MING WU REY-HENG HU PO-HUANG LEE MEI-HWEI CHANG |
公開日期: | 2008 | 卷: | 86 | 期: | 11 | 起(迄)頁: | 1531-1535 | 來源出版物: | Transplantation | 摘要: | BACKGROUND.: A hepatitis B virus (HBV) universal vaccination program for infants was implemented for 24 years in Taiwan. Most of the children who received organ transplantation were primarily vaccinated before transplantation. This study investigated the efficacy of HBV vaccination and booster responses in children after liver transplantation (LT). METHODS.: Totally 31 children were enrolled. They were clinically stable for more than 1 year after LT. Twenty of them kept a titer of antibody to hepatitis B surface antigen (anti-HBs) more than 10 mIU/mL and received no booster, while 11 received one booster because their anti-HBs titers were less than 10 mIU/mL. Cellular immunity was checked by enzyme-linked immunospot assay with interferon-γ surrogated for T-helper 1 cells and interleukin-5 for T-helper 2 before and after booster vaccine. RESULTS.: One of the non-boosters had de novo HBV infection after LT and recovered to be anti-HBs positive. The first booster restored an adequate titer in 64% (7/11) of those with anti-HBs titer less than 10 mIU/mL after LT. The four patients who failed the first booster responded well to the second dose. After the booster, the mononuclear cells of all 11 had more than one spot-forming cell for interferon-γ or interleukin-5. Transplanted girls maintained a higher antibody titer than boys. CONCLUSION.: Primary HBV vaccination or the booster dose(s) of HBV vaccine could provide adequate humoral and cellular immunity in children with LT. Copyright ? 2008 Lippincott Williams & Wilkins. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-58149341596&doi=10.1097%2fTP.0b013e318189064c&partnerID=40&md5=61d73848c2c54ce23050125f63ff7204 https://scholars.lib.ntu.edu.tw/handle/123456789/537041 |
ISSN: | 0041-1337 | DOI: | 10.1097/TP.0b013e318189064c | SDG/關鍵字: | cyclosporin; gamma interferon; hepatitis B surface antibody; hepatitis B surface antigen; interleukin 5; recombinant hepatitis B vaccine; tacrolimus; gamma interferon; hepatitis B vaccine; interleukin 5; antibody titer; article; cellular immunity; clinical article; controlled study; cytokine production; drug blood level; female; hepatitis B; human; human cell; humoral immunity; immunosuppressive treatment; liver graft rejection; liver transplantation; male; mononuclear cell; priority journal; sex difference; Th1 cell; Th2 cell; vaccination; child; helper cell; hepatitis B; immunization; infant; liver disease; liver transplantation; metabolism; preschool child; vaccination; virology; Child; Child, Preschool; Female; Hepatitis B; Hepatitis B Vaccines; Humans; Immunization Schedule; Infant; Interferon-gamma; Interleukin-5; Liver Diseases; Liver Transplantation; Male; T-Lymphocytes, Helper-Inducer; Vaccination |
顯示於: | 醫學系 |
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