https://scholars.lib.ntu.edu.tw/handle/123456789/537197
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lee C.-Y. | en_US |
dc.contributor.author | PING-ING LEE | en_US |
dc.contributor.author | LI-MIN HUANG | en_US |
dc.contributor.author | JONG-MIN CHEN | en_US |
dc.contributor.author | MEI-HWEI CHANG | en_US |
dc.creator | Lee C.-Y.;Lee P.-I.;Huang L.-M.;Chen J.-M.;Mei-Hwei Chang | - |
dc.date.accessioned | 2021-01-04T07:38:51Z | - |
dc.date.available | 2021-01-04T07:38:51Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0022-3476 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030658869&doi=10.1016%2fS0022-3476%2897%2970287-7&partnerID=40&md5=a34c376a2add8d61f1b20bf717dda2b4 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/537197 | - |
dc.description.abstract | Objective: To investigate the safety, immunogenicity, and efficacy of a simplified hepatitis B vaccination schedule. Methods: The second dose of hepatitis B vaccine and the first dose of diphtheria-tetanus-pertussis (DTP) vaccine were given simultaneously at age 6 weeks. The second dose of DTP vaccine was given at age 3.5 months. The third dOSe of DTP vaccine and the third dose of hepatitis B vaccine were given at age 5.5 months. One hundred three infants (group A) born to mothers without hepatitis B surface antigen (HBsAg) received DTP with whole-cell pertussis vaccine. Fifty-five infants (group B) born to mothers with HBsAg and hepatitis B e antigen received DTP with acellular pertussis vaccine. Results: By age 9 months, none of group A and 4 (7%) group B infants were seropositive for HBsAg. The protective efficacy against the hepatitis B carrier state in these infants at high risk was 92%. Antibody to hepatitis B surface antigen was 10 mlU/ml or greater in 99 (96%) of group A infants and in 50 (91%) of group B infants. Both the acellular and whole-cell DTP vaccines were immunogenic, and the incidences of adverse reactions were within an expected and acceptable range. Conclusions: The simplified vaccination schedule to integrate the hepatitis B vaccine into the Expanded Programme of Immunization was safe, immunogenic, and effective. This schedule may improve vaccine compliance and be applied to DTP and hepatitis B combination vaccines now under investigation. | - |
dc.publisher | Mosby Inc. | - |
dc.relation.ispartof | Journal of Pediatrics | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | diphtheria antibody; diphtheria pertussis tetanus vaccine; hepatitis B surface antibody; hepatitis B surface antigen; hepatitis B vaccine; hepatitis B(e) antigen; oral poliomyelitis vaccine; tetanus antibody; anorexia; antibody titer; article; clinical trial; controlled clinical trial; controlled study; drug efficacy; drug formulation; drug safety; endemic disease; erythema; fever; human; immunization; immunogenicity; infant; irritability; major clinical study; oral drug administration; pain; priority journal; side effect; skin manifestation; somnolence; vomiting | - |
dc.title | A simplified schedule to integrate the hepatitis B vaccine into an expanded program of immunization in endemic countries | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/S0022-3476(97)70287-7 | - |
dc.identifier.pmid | 9202623 | - |
dc.identifier.scopus | 2-s2.0-0030658869 | - |
dc.relation.pages | 981-986 | - |
dc.relation.journalvolume | 130 | - |
dc.relation.journalissue | 6 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | National Taiwan University Children's Hospital | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.orcid | 0000-0002-7299-2825 | - |
crisitem.author.orcid | 0000-0002-9291-260X | - |
crisitem.author.orcid | 0000-0002-3648-9261 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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