https://scholars.lib.ntu.edu.tw/handle/123456789/537204
標題: | Mother-to-infant transmission of hepatitis C virus | 作者: | MEI-HWEI CHANG | 公開日期: | 1996 | 卷: | 19 | 期: | 5 | 起(迄)頁: | 368-372 | 來源出版物: | Clinical and Investigative Medicine | 摘要: | Mother-to-infant (vertical) transmission of hepatitis C virus (HCV) has been documented, but vertical transmission of HCV is less efficient (affecting 0% to 15% [mean 4.7%] of the infants of mothers with HCV infection) than that of hepatitis B virus. This lower rate of vertical transmission is likely due to the lower viral level of HCV in the sera of most mothers with an infection. Infants of mothers with an HCV and HIV coinfection or with a high HCV RNA titre (greater than 1 million copies per millilitre) are at a high risk of HCV infection (with a mean 39% of infants of mothers with HCV and HIV coinfection having an HCV infection). In most infants (81%) with an HCV infection studied longitudinally, the infection is persistent, and the alanine aminotransferase levels are transiently or persistently abnormal; however, normal liver function is also observed in some patients. There is currently no effective way to prevent vertical transmission of HCV. Further investigation aimed at better understanding the natural history of perinatal HCV infection and the indications for antiviral therapy is needed. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029828305&partnerID=40&md5=7f125f72a562daefc50b4975a2d91a89 https://scholars.lib.ntu.edu.tw/handle/123456789/537204 |
ISSN: | 0147-958X | SDG/關鍵字: | alanine aminotransferase; antivirus agent; virus rna; adult; alanine aminotransferase blood level; blood level; breast feeding; conference paper; disease course; female; hepatitis b virus; hepatitis c; hepatitis c virus; human; human immunodeficiency virus; liver function; major clinical study; newborn; priority journal; risk factor; vertical transmission; virus transmission; Disease Transmission, Vertical; Female; Hepacivirus; Hepatitis C; Humans; Infant; Pregnancy; Pregnancy Complications, Infectious |
顯示於: | 醫學系 |
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