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  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/537235
DC FieldValueLanguage
dc.contributor.authorTsuei D.J.en_US
dc.contributor.authorHsu T.Y.en_US
dc.contributor.authorChen J.Y.en_US
dc.contributor.authorMEI-HWEI CHANGen_US
dc.contributor.authorHsu H.C.en_US
dc.contributor.authorYang C.S.en_US
dc.date.accessioned2021-01-04T07:39:01Z-
dc.date.available2021-01-04T07:39:01Z-
dc.date.issued1994-
dc.identifier.issn0146-6615-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0028348904&doi=10.1002%2fjmv.1890420316&partnerID=40&md5=75deef601d1ba76fb2984b8ef5903f6c-
dc.identifier.urihttps://scholars.lib.ntu.edu.tw/handle/123456789/537235-
dc.description.abstractThe DNA of tumor tissue K1 obtained at autopsy from a case of hepatocellular carcinoma (HCC) in a 9?year?old boy contained integrated hepatitis B virus (HBV) DNA at a single site in the chromosome (case 2, Chang et al.: Hepatology 13:316?320, 1991). To characterize further the integrated viral DNA sequences, a genomic library of the K1 DNA was constructed in the lambda L47.1 vector. One phage clone, designated KTM?1, containing integrated HBV DNA and cellular flanking sequences was obtained from this library. The restriction map and DNA sequence of this clone showed that the integrated HBV DNA was partially deleted and rearranged. The most conserved viral DNA sequences were surface and X genes and arranged in the opposite orientation. The viral core gene was not present. Using chloramphenicol acetyltransferase (CAT) assay, the C?terminal truncated X open reading frame was demonstrated to retain its trans?activating ability. The result suggested that the functional integrated X gene may play a role in hepatocarcinogenesis. The study also showed that the right cellular flanking sequences were human alphoid repetitive sequences. ? 1994 Wiley?Liss, Inc. Copyright ? 1994 Wiley?Liss, Inc., A Wiley Companyen_US
dc.relation.ispartofJournal of Medical Virologyen_US
dc.subjectchildhood hepatocellular carcinoma; hepatitis B virus; hepatocarcinogene?sis; repetitive squences; trans?activationen_US
dc.subject.otherarticle; carcinogenesis; child; hepatitis b; hepatitis b virus; human; human tissue; liver cell carcinoma; male; restriction mapping; transactivation; Base Sequence; Carcinoma, Hepatocellular; Child; Comparative Study; DNA, Neoplasm; DNA, Viral; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Viral; Hepatitis B; Hepatitis B Virus; Human; Liver Neoplasms; Male; Molecular Sequence Data; Open Reading Frames; Sequence Homology, Nucleic Acid; Support, Non-U.S. Gov't; Trans-Activation (Genetics); Virus Integration-
dc.subject.other[SDGs]SDG3-
dc.titleAnalysis of integrated hepatitis B virus DNA and flanking cellular sequences in a childhood hepatocellular carcinomaen_US
dc.typejournal articleen_US
dc.identifier.doi10.1002/jmv.1890420316-
dc.identifier.pmid8006642-
dc.identifier.scopus2-s2.0-0028348904-
dc.relation.pages287-293en_US
dc.relation.journalvolume42en_US
dc.relation.journalissue3en_US
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_6501-
item.fulltextno fulltext-
item.cerifentitytypePublications-
item.openairetypejournal article-
crisitem.author.deptPediatrics-NTUH-
crisitem.author.deptPediatrics-
crisitem.author.orcid0000-0002-3648-9261-
crisitem.author.parentorgNational Taiwan University Hospital-
crisitem.author.parentorgCollege of Medicine-
Appears in Collections:醫學系
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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

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