https://scholars.lib.ntu.edu.tw/handle/123456789/537254
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | YEN-HSUAN NI | en_US |
dc.contributor.author | HONG-YUAN HSU | en_US |
dc.contributor.author | MEI-HWEI CHANG | en_US |
dc.contributor.author | Chen D.-S. | en_US |
dc.contributor.author | Lee C.-Y. | en_US |
dc.creator | Ni Y.-H.;Hsu H.-Y.;Mei-Hwei Chang;Chen D.-S.;Lee C.-Y. | - |
dc.date.accessioned | 2021-01-04T07:41:05Z | - |
dc.date.available | 2021-01-04T07:41:05Z | - |
dc.date.issued | 1993 | - |
dc.identifier.issn | 0168-8278 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027500114&doi=10.1016%2fS0168-8278%2805%2980030-3&partnerID=40&md5=661e7334596f712c8e6e9d6d812c1caa | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/537254 | - |
dc.description.abstract | An absence of the hepatitis B core antibody (anti-HBc) in hepatitis B surface antigen (HBsAg) carrier children has been reported before, but whether anti-HBc will ultimately appear is unknown. In a group of 420 HBsAg carrier children who were followed longitudinally, 10 (2.4%) had an absence or delayed appearance of serum anti-HBc. These 10 children were persistently seropositive for HBsAg, hepatitis B e-antigen, and hepatitis B virus DNA (HBV-DNA). Anti-HBc never appeared in 4, one of whom was a case of hepatitis B vaccine failure and became an HBsAg carrier. Three of the 4 were born to HBsAg carrier mothers. Liver biopsy in one revealed non-specific reactive hepatitis (NSRH). All 4 were asymptomatic during follow-up. Mothers of the other 6 children who had delayed appearance of anti-HBc were also HBsAg carriers. The children seroconverted to anti-HBc positivity between 2 and 8 years of age, and the titer of serum anti-HBc at the first appearance varied. There were no significant changes in liver function tests, HBV-DNA levels, or associated symptoms and signs before and after seroconversion. Liver biopsies were performed before anti-HBc seroconversion in 2 children and showed NSRH. All 10 children had a moderate to high replication of HBV as shown by the high titer of HBsAg and HBV-DNA. The absence of anti-HBc occurred almost exclusively in children who were infected perinatally. The delayed appearance of anti-HBc in our cases suggests that although an immune tolerance to hepatitis B core antigen exists in early infancy, this tolerance eventually wanes with anti-HBc formation, and is not associated with marked hepatocellular damage as revealed by insignificant changes in biochemical, viral and serological data before and after anti-HBc seroconversion. ? 1993 Elsevier Scientific Publishers Ireland Ltd. All rights reserved. | - |
dc.relation.ispartof | Journal of Hepatology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | hepatitis b core antibody; hepatitis b surface antigen; article; child; controlled study; female; hepatitis b; human; infant; major clinical study; male; priority journal; seroconversion; Biological Markers; Carrier State; Child; Child, Preschool; DNA, Viral; Female; Follow-Up Studies; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B Virus; Human; Infant; Infant, Newborn; Liver; Male; Support, Non-U.S. Gov't; Time Factors | - |
dc.title | Absence or delayed appearance of hepatitis B core antibody in chronic hepatitis B surface antigen carrier children | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/S0168-8278(05)80030-3 | - |
dc.identifier.pmid | 8445229 | - |
dc.identifier.scopus | 2-s2.0-0027500114 | - |
dc.relation.pages | 150-154 | - |
dc.relation.journalvolume | 17 | - |
dc.relation.journalissue | 2 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.orcid | 0000-0002-1158-5249 | - |
crisitem.author.orcid | 0000-0002-5720-4835 | - |
crisitem.author.orcid | 0000-0002-3648-9261 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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