https://scholars.lib.ntu.edu.tw/handle/123456789/537547
標題: | Acute and chronic arsenic poisoning associated with treatment of acute promyelocytic leukaemia | 作者: | SHANG-YI HUANG Chang C.-S. JIH-LUH TANG HWEI-FANG TIEN Kuo T.-L.I. Huang S.-F. Yao Y.U.-T. WEN-CHIEN CHOU Chung C.-Y. Wang C.-H. MING-CHING SHEN YAO-CHANG CHEN |
公開日期: | 1998 | 卷: | 103 | 期: | 4 | 起(迄)頁: | 1092-1095 | 來源出版物: | British Journal of Haematology | 摘要: | Seven relapsed and/or refractory acute promyelocytic leukaemia patients were treated by arsenic trioxide (As2O3). Four patients (4/7, 57%) achieved complete remission after one to three cycles of treatment and the most common acute side-effect was fluid retention (in six patients, 86%), including weight gains and pleuro-pericardial effusions. Evident polyneuropathy compatible with chronic arsenic toxicity was noted in two of the three patients who received As2O3 maintenance therapy and one of them had marked distal muscular atrophy. We suggest that As2O3 may be a useful salvage therapy for relapsed and refractory APL patients, but the acute or chronic arsenic toxicity should be carefully monitored. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032424777&doi=10.1046%2fj.1365-2141.1998.01079.x&partnerID=40&md5=ccffd15ea3e61968ab3765999fac6ae7 https://scholars.lib.ntu.edu.tw/handle/123456789/537547 |
ISSN: | 0007-1048 | DOI: | 10.1046/j.1365-2141.1998.01079.x | SDG/關鍵字: | arsenic trioxide; acute myeloblastic leukemia; article; body weight disorder; cancer recurrence; clinical article; fluid retention; human; intoxication; muscle atrophy; polyneuropathy; priority journal; salvage therapy; weight reduction; Acute Disease; Antineoplastic Agents; Arsenicals; Chronic Disease; Humans; Leukemia, Promyelocytic, Acute; Oxides; Recurrence |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。