https://scholars.lib.ntu.edu.tw/handle/123456789/537575
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lin K.‐H. | en_US |
dc.contributor.author | Su I.‐J. | en_US |
dc.contributor.author | Chen R.‐L. | en_US |
dc.contributor.author | Lin D.‐T. | en_US |
dc.contributor.author | HWEI-FANG TIEN | en_US |
dc.contributor.author | Chen B.‐W. | en_US |
dc.contributor.author | Lin K.‐S. | en_US |
dc.date.accessioned | 2021-01-04T12:13:14Z | - |
dc.date.available | 2021-01-04T12:13:14Z | - |
dc.date.issued | 1994 | - |
dc.identifier.issn | 0098-1532 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028234458&doi=10.1002%2fmpo.2950230106&partnerID=40&md5=b7da89bbde50a8047ab8a710c46e2f29 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/537575 | - |
dc.description.abstract | We encountered five children with peripheral T?cell lymphoma (PTL) at National Taiwan University Hospital (NTUH) from 1985–1989. The patients were four boys and one girl, aged between 5 and 13 years. The duration of prediagnostic symptoms varied from 1 month to 5 years. All had pyrexia and lymphadenopathy; one had a prolonged history of granulomatosis with repeated infection. Four had hepatosplenomegaly. One patient presented with diffuse pulmonary infiltration and impending respiratory failure. All patients were negative for human T?cell leukemia virus (HTLV)?I antibody, and positive for HBsAg. Four patients who had EBV?viral capsid antigen (VCA) IgG and who were IgM tested were positive for EBV?VCA IgG, but only two had evidence of active EBV infection. Tumor cell markers were examined and showed the following phenotypes: all patients were CD2, CD3, and CD7 positive but CD19 and CD20 negative; three patients were CD4 positive and CD8 negative; the other two patients were CD4 negative and CD8 positive. Four patients died 2–7 months after diagnosis. The remaining patient received allogeneic bone marrow transplantation and has survived free of disease for more than 22 months after transplant. Our five cases reconfirm the high frequency of diagnostic delay, the heterogenous immunophenotypes, high mortality, and poor responsiveness to conventional therapy for PTL. Bone marrow transplantation in the early stage might be a possible cure of this disease. ?1994 Wiley?Liss, inc. Copyright ? 1994 Wiley?Liss, Inc., A Wiley Company | - |
dc.relation.ispartof | Medical and Pediatric Oncology | - |
dc.subject | bone marrow transplant; EBV infection; pyrexia and lymphadenopathy | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | antineoplastic agent; bleomycin; busulfan; cd19 antigen; cd2 antigen; cd3 antigen; cd4 antigen; cd8 antigen; cyclophosphamide; doxorubicin; hepatitis b surface antigen; human t cell leukemia virus antibody; immunoglobulin g; immunoglobulin m; methotrexate; prednisolone; procarbazine; vincristine; virus capsid antigen; adolescent; antigen expression; article; bone marrow transplantation; cancer combination chemotherapy; child; childhood cancer; chromosome aberration; clinical article; clinical feature; clinical trial; epstein barr virus; female; histopathology; human; immunophenotyping; lung biopsy; lung metastasis; lymph node biopsy; lymph node metastasis; male; preschool child; priority journal; school child; t cell lymphoma; taiwan; virus capsid; virus detection; Adolescent; Antibodies, Viral; Case Report; Child; Female; Human; Immunophenotyping; Lymphoma, T-Cell, Peripheral; Male; Taiwan | - |
dc.title | Peripheral T‐cell lymphoma in childhood: A report of five cases in Taiwan | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/mpo.2950230106 | - |
dc.identifier.pmid | 8177142 | - |
dc.identifier.scopus | 2-s2.0-0028234458 | - |
dc.relation.pages | 26-35 | - |
dc.relation.journalvolume | 23 | - |
dc.relation.journalissue | 1 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-1384-5593 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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