https://scholars.lib.ntu.edu.tw/handle/123456789/537623
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | TUNG-HUNG SU | en_US |
dc.contributor.author | CHUN-JEN LIU | en_US |
dc.contributor.author | TAI-CHUNG TSENG | en_US |
dc.contributor.author | Chou S.-W | en_US |
dc.contributor.author | CHEN-HUA LIU | en_US |
dc.contributor.author | HUNG-CHIH YANG | en_US |
dc.contributor.author | SHANG-JU WU | en_US |
dc.contributor.author | PEI-JER CHEN | en_US |
dc.contributor.author | DING-SHINN CHEN | en_US |
dc.contributor.author | CHI-LING CHEN | en_US |
dc.contributor.author | JIA-HORNG KAO | en_US |
dc.date.accessioned | 2021-01-05T00:56:24Z | - |
dc.date.available | 2021-01-05T00:56:24Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0269-2813 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85060568076&doi=10.1111%2fapt.15132&partnerID=40&md5=5fc36ffd55a9b68c41266033dd8de908 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/537623 | - |
dc.description.abstract | Background: Chronic hepatitis B has been linked to lymphoma with contradictory results. Aim: To investigate the association between chronic hepatitis B and lymphoma by using a nationwide population-based cohort. Methods: Records of patients diagnosed with chronic hepatitis B (hepatitis B virus [HBV] cohort) or without (non-HBV cohort) during 2004-2007 were retrieved from the Taiwan National Health Insurance Research Database. Age, sex, comorbidities, and medical visits were matched using propensity scores between both cohorts, and they were followed up longitudinally until 2012 to determine any new lymphoma development. Results: A total of 203?031 patients were included in each cohort with a mean follow-up of 7-9?years. The lymphoma incidence rate was significantly higher in the HBV cohort than in the non-HBV cohort (29.4 vs 15.9 per 100?000 person-years, P?<?0.0001). After adjustment for comorbidities and medical visits, HBV infection was found to be an independent risk factor associated with the development of lymphoma (hazard ratio [HR]: 2.07, 95% confidence interval [CI]: 1.76-2.43, P?<?0.0001) and non-Hodgkin's lymphoma (HR: 2.18, 95% CI: 1.80-2.65, P?<?0.0001); specifically with an increased risk of diffuse large B-cell lymphoma (HR: 2.69, 95% CI: 2.05-3.52, P?<?0.0001), other B-cell lymphoma (HR: 3.11, 95% CI: 1.89-5.11, P?<?0.0001), and also for multiple myeloma (HR: 1.63, 95% CI: 1.10-2.42, P?=?0.016). The association was significant even after excluding lymphoma development within the first year (HR: 2.08, 95% CI: 1.75-2.47, P?<?0.0001). Conclusions: Chronic hepatitis B is temporally associated with a 2-fold increased risk of lymphoma, particularly with B-cell non-Hodgkin's lymphoma, and also an increased risk for multiple myeloma. ? 2019 John Wiley & Sons Ltd | en_US |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.relation.ispartof | Alimentary Pharmacology and Therapeutics | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | adefovir; alanine aminotransferase; entecavir; lamivudine; peginterferon alpha; telbivudine; adult; alanine aminotransferase blood level; Article; B cell lymphoma; cancer incidence; cancer risk; chronic hepatitis B; cohort analysis; comorbidity; controlled study; diffuse large B cell lymphoma; disease association; female; health insurance; hepatitis B; human; longitudinal study; major clinical study; male; multiple myeloma; nonhodgkin lymphoma; priority journal; propensity score; risk factor; Taiwan; aged; B cell lymphoma; chronic hepatitis B; follow up; hepatitis B; Hepatitis B virus; middle aged; multiple myeloma; Adult; Aged; Cohort Studies; Comorbidity; Female; Follow-Up Studies; Hepatitis B; Hepatitis B virus; Hepatitis B, Chronic; Humans; Longitudinal Studies; Lymphoma, B-Cell; Male; Middle Aged; Multiple Myeloma; Risk Factors; Taiwan | - |
dc.title | Chronic hepatitis B is associated with an increased risk of B-cell non-Hodgkin's lymphoma and multiple myeloma | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1111/apt.15132 | - |
dc.identifier.pmid | 30681172 | - |
dc.identifier.scopus | 2-s2.0-85060568076 | - |
dc.relation.pages | 589-598 | en_US |
dc.relation.journalvolume | 49 | en_US |
dc.relation.journalissue | 5 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Medical Research | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Microbiology | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-6747-7941 | - |
crisitem.author.orcid | 0000-0002-6202-0993 | - |
crisitem.author.orcid | 0000-0003-3622-9707 | - |
crisitem.author.orcid | 0000-0003-3864-9895 | - |
crisitem.author.orcid | 0000-0002-0772-869X | - |
crisitem.author.orcid | 0000-0001-8316-3785 | - |
crisitem.author.orcid | 0000-0001-7791-6154 | - |
crisitem.author.orcid | 0000-0002-2442-7952 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。