https://scholars.lib.ntu.edu.tw/handle/123456789/537786
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Huang M.-T. | en_US |
dc.contributor.author | Chou C.-C. | en_US |
dc.contributor.author | SHIANN-TANG JOU | en_US |
dc.contributor.author | KAI-HSIN LIN | en_US |
dc.contributor.author | Hsieh K.-H. | en_US |
dc.creator | Huang M.-T.;Chou C.-C.;Shiann-Tang Jou;Lin K.-H.;Hsieh K.-H. | - |
dc.date.accessioned | 2021-01-05T02:29:10Z | - |
dc.date.available | 2021-01-05T02:29:10Z | - |
dc.date.issued | 1996 | - |
dc.identifier.issn | 0125-877X | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030418645&partnerID=40&md5=e64b28b34f4a47e3e246ceb2755581b2 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/537786 | - |
dc.description.abstract | We describe the successful use of HLA-compatible sibling bone marrow transplantation (BMT) in a 17-month-old Chinese boy in whom Wiskott-Aldrich syndrome (WAS) was diagnosed on the basis of eczema, thrombocytopenia, recurrent otitis media and abnormal immunological tests. The conditioning chemotherapy included 2 days' oral busulfan, 40 mg/m2/6 hours, and 2 days' intravenous cyclophosphamide, 60 mg/kg/day (BU2CY2). Complete hematological chimerism was achieved 3 weeks after transplantation. Eight months after his BMT the eczema has resolved, platelet count is normal, and he no longer has frequent infections. BU2CY2 as a preconditioning regimen gave complete lymphohematopoietic engraftment in this WAS patient with no evidence of graft- versus- host disease. The excellent clinical response of this patient and the inevitable fatal outcome of WAS support the opinion that where a histocompatible donor is available, BMT at the earliest opportunity is the best option. We believe this is the first case of successful BMT in a Chinese patient with WAS. | en_US |
dc.relation.ispartof | Asian Pacific Journal of Allergy and Immunology | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | busulfan; cyclophosphamide; immunosuppressive agent; article; bone marrow transplantation; case report; child; chinese; eczema; human; intravenous drug administration; male; oral drug administration; otitis media; preschool child; thrombocytopenia; wiskott aldrich syndrome; Asian Continental Ancestry Group; Bone Marrow Transplantation; Busulfan; Cyclophosphamide; Humans; Infant; Male; Wiskott-Aldrich Syndrome | - |
dc.title | Successful bone marrow transplantation in a Chinese boy with Wiskott-Aldrich syndrome | en_US |
dc.type | journal article | en |
dc.identifier.pmid | 8980801 | - |
dc.identifier.scopus | 2-s2.0-0030418645 | - |
dc.relation.pages | 57-63 | en_US |
dc.relation.journalvolume | 14 | en_US |
dc.relation.journalissue | 1 | en_US |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.orcid | 0000-0003-1483-0403 | - |
crisitem.author.orcid | 0000-0002-5833-7066 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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