https://scholars.lib.ntu.edu.tw/handle/123456789/537934
Title: | Dextran-coated iron oxide nanoparticles turn protumor mesenchymal stem cells (MSCs) into antitumor MSCs | Authors: | Chung T.-H. Hsieh C.-C. Hsiao J.-K. SZU-CHUN HSU MING YAO Huang D.-M. |
Issue Date: | 2016 | Publisher: | Royal Society of Chemistry | Journal Volume: | 6 | Journal Issue: | 51 | Start page/Pages: | 45553-45561 | Source: | RSC Advances | Abstract: | Mesenchymal stem cells or multipotent mesenchymal stromal cells (MSCs) with tumor tropism have shown promise as a cellular deliverer of anticancer agents for cancer therapy. However, despite the fact that engineered MSCs have demonstrated profound anticancer effects, the exact intrinsic impact of MSCs themselves on tumor progression is still being debated. Therefore, in order to ensure pertinent MSC-based cancer therapy, it is essential to further explore the intrinsic antitumor and protumor effects of MSCs on tumor progression. Here, we show that dextran-coated iron oxide nanoparticles can not only increase the antitumor effect of antitumor MSCs but also reverse the protumor effect of protumor MSCs and hence turn protumor MSCs into antitumor MSCs in vivo, which can be attributed to the in vitro finding that dextran-coated iron oxide nanoparticles can not only inhibit the colony formation of cancer cells likely through induction of cytokine receptor expression to competitively capture the tumorous cytokine but also diminish cancer-mediated fibroblast differentiation and angiogenesis of protumor MSCs. This is the first report to demonstrate the induction of antitumor MSCs from protumor MSCs. ? 2016 The Royal Society of Chemistry. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84970028637&doi=10.1039%2fc6ra03453e&partnerID=40&md5=51ec3dd4276a7fcbd1e83e121200de53 https://scholars.lib.ntu.edu.tw/handle/123456789/537934 |
ISSN: | 2046-2069 | DOI: | 10.1039/c6ra03453e | SDG/Keyword: | Cells; Cytology; Dextran; Diseases; Flowcharting; Iron; Iron oxides; Metal nanoparticles; Nanoparticles; Oncology; Stem cells; Tumors; Anti-cancer agents; Anticancer effects; Colony formation; Cytokine receptor; Iron oxide nanoparticle; Mesenchymal stem cell; Multipotent mesenchymal stromal cells; Tumor progressions; Cell culture |
Appears in Collections: | 醫學系 |
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