https://scholars.lib.ntu.edu.tw/handle/123456789/537969
標題: | Iron oxide nanoparticle-induced epidermal growth factor receptor expression in human stem cells for tumor therapy | 作者: | Chung T.-H. Hsiao J.-K. SZU-CHUN HSU MING YAO YAO-CHANG CHEN Wang S.-W. YEN-PING KUO Yang C.-S. Huang D.-M. |
公開日期: | 2011 | 卷: | 5 | 期: | 12 | 起(迄)頁: | 9807-9816 | 來源出版物: | ACS Nano | 摘要: | Superparamagnetic iron oxide (SPIO) nanoparticles show promise as labels for cellular magnetic resonance imaging (MRI) in the application of stem cell-based therapy. However, the unaddressed concerns about the impact of SPIO nanoparticles on stem cell attributes make the feasibility of SPIO labeling uncertain. Here, we show that the labeling of human mesenchymal stem cells (hMSCs) with ferucarbotran can induce epidermal growth factor receptor (EGFR) overexpression. Labeled hMSCs with their overexpressed EGFR were attracted by tumorous EGF and more effectively migrated toward tumor than unlabeled cells, resulting in more potent intrinsic antitumor activity. Moreover, the captured binding of tumorous EGF by overexpressed EGFR of labeled hMSCs blocked EGF/EGFR signaling-derived tumor growth, tumorous angiogenesis, and tumorous VEGF expression also responsible for tumor progression and development. Our results show that the impact of SPIO nanoparticles on stem cell attributes is not necessarily harmful but can be cleverly used to be beneficial to stem cell-based therapy. ? 2011 American Chemical Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84555163667&doi=10.1021%2fnn2033902&partnerID=40&md5=c180828d5ef220e5537074bd2007f96e https://scholars.lib.ntu.edu.tw/handle/123456789/537969 |
ISSN: | 1936-0851 | DOI: | 10.1021/nn2033902 | SDG/關鍵字: | Angiogenesis; Anti-tumor activities; Cancer therapy; Cell-based therapy; Epidermal growth factor receptors; Human mesenchymal stem cells (hMSCs); iron oxide nanoparticle; Mesenchymal stem cell; Over-expression; Superparamagnetic iron oxide nanoparticles; Tumor growth; Tumor progressions; Tumor therapy; Cell culture; Iron; Magnetic resonance imaging; Nanomagnetics; Nanoparticles; Peptides; Stem cells; Superparamagnetism; Tumors; Iron oxides; contrast medium; dextran; EGFR protein, human; epidermal growth factor receptor; ferumoxtran-10; magnetite nanoparticle; nanoparticle; ultrasmall superparamagnetic iron oxide; animal; article; cell survival; colon tumor; cytology; drug effect; human; mesenchymal stem cell; mesenchymal stem cell transplantation; metabolism; methodology; mouse; multimodality cancer therapy; treatment outcome; tumor cell line; Animals; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Combined Modality Therapy; Contrast Media; Dextrans; Humans; Magnetite Nanoparticles; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Nanoparticles; Receptor, Epidermal Growth Factor; Treatment Outcome |
顯示於: | 醫學系 |
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