https://scholars.lib.ntu.edu.tw/handle/123456789/538222
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Kang Y.-N. | en_US |
dc.contributor.author | Chi S.-C. | en_US |
dc.contributor.author | MEI-HWAN WU | en_US |
dc.contributor.author | Chiu H.-H. | en_US |
dc.creator | Kang Y.-N.;Chi S.-C.;Mei-Hwan Wu;Chiu H.-H. | - |
dc.date.accessioned | 2021-01-05T08:06:40Z | - |
dc.date.available | 2021-01-05T08:06:40Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 0929-6646 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064242694&doi=10.1016%2fj.jfma.2019.03.018&partnerID=40&md5=500cceeeff4abdcb2fd7af4d56c541d3 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/538222 | - |
dc.description.abstract | Background and purpose: Variable effects of beta-blockers (BB) and/or angiotensin receptor blockers (ARB) were reported to retard aortic root growth in Marfan syndrome (MFS). This study aimed to compare the effects of BB therapy and ARB-related therapies on cardiovascular protection in MFS. Methods: Studies of randomized control trials comparing the efficacy of only-BB and ARB-related (only-ARB or ARB-plus-BB) therapies for MFS published before July 31, 2018 in PubMed, Embase, and the Cochrane Library were selected. The outcomes included changes in aortic growth and cardiovascular events. Results: Eight trials involving 1381 patients were included. Patients received only-BB and ARB-related therapies did not differ significantly in changes in aortic growth (aortic root diameter: standardized mean difference [SMD] = 0.04, 95% confidence interval [CI]: ?0.11–0.19, p = 0.63) or cardiovascular events (aortic dissection: Peto odds ratio [OR] = 1.67, 95% CI: 0.42–6.72, p = 0.47; aortic surgery: risk ratio = 0.97, 95% CI: 0.66–1.41, p = 0.86; death: Peto OR = 2.78, 95% CI: 0.39–19.82, p = 0.31). Subgroup analysis revealed that ARB-plus-BB therapy exhibited nonsignificantly better outcomes than only-BB therapy (aortic root diameter: SMD = 0.11, 95% CI: ?0.22–0.45, p = 0.52; ascending aorta diameter: SMD = 0.10, 95% CI: ?0.07–0.27, p = 0.26; aortic surgery: Peto OR = 1.10, 95% CI: 0.75–1.61, p = 0.62). Conclusion: For cardiovascular protection in MFS, only-ARB therapy is not inferior to only-BB therapy. Moreover, the outcomes of ARB-plus-BB therapy seemed to be favourable to those of only-BB therapy. ? 2019 Formosan Medical Association | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.ispartof | Journal of the Formosan Medical Association | - |
dc.subject | Angiotensin receptor blocker; Aortic aneurysm; Beta blocker; Losartan; Marfan | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | beta adrenergic receptor blocking agent; losartan; angiotensin receptor antagonist; beta adrenergic receptor blocking agent; cardiotonic agent; losartan; aortic dissection; aortic surgery; Article; cardiovascular risk; Cochrane Library; comparative effectiveness; drug effect; Embase; heart protection; human; Marfan syndrome; Medline; meta analysis; outcome assessment; quality control; systematic review; aortic disease; combination drug therapy; lesions and defects; Marfan syndrome; randomized controlled trial (topic); treatment outcome; Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Aortic Diseases; Cardiotonic Agents; Dilatation, Pathologic; Drug Therapy, Combination; Humans; Losartan; Marfan Syndrome; Randomized Controlled Trials as Topic; Treatment Outcome | - |
dc.title | The effects of losartan versus beta-blockers on cardiovascular protection in marfan syndrome: A systematic review and meta-analysis | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jfma.2019.03.018 | - |
dc.identifier.pmid | 31003918 | - |
dc.identifier.scopus | 2-s2.0-85064242694 | - |
dc.relation.pages | 182-190 | - |
dc.relation.journalvolume | 119 | - |
dc.relation.journalissue | 1P1 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Clinical Pharmacy | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.orcid | 0000-0002-7074-8087 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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