https://scholars.lib.ntu.edu.tw/handle/123456789/538278
標題: | Risk of Systemic Hypertension and Cerebrovascular Accident in Patients with Aortic Coarctation Aged <60 Years (from a National Database Study) | 作者: | MEI-HWAN WU Chen H.-C. Kao F.-Y. Huang S.-K. |
公開日期: | 2015 | 出版社: | Elsevier Inc. | 卷: | 116 | 期: | 5 | 起(迄)頁: | 779-784 | 來源出版物: | American Journal of Cardiology | 摘要: | Patients with coarctation of the aorta (CoA) may develop hypertension and cerebrovascular accident (CVA) late after intervention, but the risk is still unclear. Therefore, we studied the epidemiologic profile from a general population aged <60 years to assess the relative risk. Our study population consisted of 126,943 patients with congenital heart disease (CHD) derived from Taiwan's National Health Insurance database from 2000 to 2010 (population 22,765,535). There were 2,295 patients with CoA (50.3% men) (prevalence: 0.116/1000). Associated cardiac lesions in 44% of the patients with CoA included ventricular septal defect (VSD; 23.3%), patent ductus arteriosus (7.5%), atrial septal defect (9.0%), and so forth. Hypertension occurred in 190 patients (8.3%) and was related to age, without associated VSD (odds ratio [OR] 5.90, 95% confidence interval [CI] 2.12 to 16.39, p = 0.001) and male gender (OR 1.59, 95% CI 1.09 to 2.30, p = 0.015). The incidence of hypertension increased rapidly in the young adulthood and was 1.36% in pediatric age group and 28.9% and 45.7% in age group 20 to 29 and 30 to 39, respectively. CVA occurred in 29 patients (1.67%), and the coexisting hypertension was the single predictor (OR 3.19, 95% CI 1.13 to 9.00, p = 0.029). Furthermore, in all patients with CHD, CoA was an independent risk factor for hypertension (OR 15.65, 95% CI 12.44 to 19.68, p <0.001) and CVA (OR 6.55, 95% CI 4.41 to 9.74, p <0.001). Comparing with non-CoA CHD patients, patients with CoA, particularly men, adult, and patients without VSD, have high risk of hypertension, which would further increase the risk of CVA. Early recognition and timely intervention for the hypertension in patients with CoA is mandatory. ? 2015 Elsevier Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84952872135&doi=10.1016%2fj.amjcard.2015.05.052&partnerID=40&md5=f30e96a6db2aa1689dbda2c4d40b6e24 https://scholars.lib.ntu.edu.tw/handle/123456789/538278 |
ISSN: | 0002-9149 | DOI: | 10.1016/j.amjcard.2015.05.052 | SDG/關鍵字: | adolescent; adult; adulthood; age; aorta coarctation; Article; cerebrovascular accident; child; disease association; disease predisposition; female; gender; heart atrium septum defect; heart ventricle septum defect; human; hypertension; infant; major clinical study; male; middle aged; newborn; patent ductus arteriosus; priority journal; risk assessment; young adult; age distribution; aged; Aortic Coarctation; clinical trial; complication; follow up; hypertension; incidence; multicenter study; prevalence; procedures; prognosis; register; retrospective study; risk factor; statistics and numerical data; Stroke; survival rate; Taiwan; time; trends; Adult; Age Distribution; Age Factors; Aged; Aortic Coarctation; Female; Follow-Up Studies; Humans; Hypertension; Incidence; Male; Middle Aged; Prevalence; Prognosis; Registries; Retrospective Studies; Risk Assessment; Risk Factors; Stroke; Survival Rate; Taiwan; Time Factors; Young Adult |
顯示於: | 醫學系 |
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