https://scholars.lib.ntu.edu.tw/handle/123456789/538664
Title: | Association study of cyclooxygenase 2 single nucleotide polymorphisms and childhood acute lymphoblastic leukemia in Taiwan | Authors: | Wang C.-H. Wu K.-H. YUNG-LI YANG Peng C.-T. Wang R.-F. Tsai C.-W. Tsai R.-Y. Linn D.-T. Tsai F.-J. Bau D.-T. |
Keywords: | Childhood leukemia; Cox-2; Polymorphism | Issue Date: | 2010 | Publisher: | International Institute of Anticancer Research | Journal Volume: | 30 | Journal Issue: | 9 | Start page/Pages: | 3649-3653 | Source: | Anticancer Research | Abstract: | Aim: The relationship between COX-2 gene and childhood leukemia risk is ambiguous. In this study, the association of genotypic polymorphisms in cyclooxygenase 2 (Cox-2) with childhood leukemia were investigated. Materials and Methods: A total of 266 patients with childhood leukemia and 266 healthy controls recruited from the China Medical Hospital in central Taiwan were genotyped by PCR-RFLP method. Six polymorphic variants of Cox-2 were investigated, including G-1195A, G-765C, T+8473C, intron 1, intron 5, and intron 6, and the associations of specific genotypes with susceptibility to childhood leukemia were analysed. Results: The data showed that although there was no difference in the distribution for each genotype of Cox-2 G-1195A, G-765C, T+8473C, intron 1, intron 5, and intron 6, between the childhood leukemia and control groups (p>0.05), the analysis of combined effect for COX-2 G-765C and intron 6 showed that individuals with GC at G-765C and GG or AG+AA at intron 6 present a slightly higher potential for developing childhood leukemia than other groups. Conclusion: These findings suggest that the C allele of COX-2 G-765C may be responsible for childhood leukemia and may be useful in early detection of child leukemia. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77958604385&partnerID=40&md5=3bdd833724ef3e0dc7de4b4686915d0b https://scholars.lib.ntu.edu.tw/handle/123456789/538664 |
ISSN: | 0250-7005 | SDG/Keyword: | cyclooxygenase 2; cyclooxygenase 2; acute lymphoblastic leukemia; article; child; childhood leukemia; controlled study; female; genetic association; genotype; human; intron; major clinical study; male; preschool child; priority journal; school child; single nucleotide polymorphism; Taiwan; acute lymphoblastic leukemia; genetic predisposition; genetics; polymerase chain reaction; restriction fragment length polymorphism; single nucleotide polymorphism; Child; Cyclooxygenase 2; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Male; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Taiwan |
Appears in Collections: | 醫學系 |
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