https://scholars.lib.ntu.edu.tw/handle/123456789/538760
標題: | Haematopoietic stem cell transplantation in Taiwan: Past, present, and future | 作者: | Chen P.M. Hsiao L.T. JIH-LUH TANG Yen C.C. Liu J.H. Chiou T.J. Tzeng C.H. KAI-HSIN LIN |
關鍵字: | Hematopoietic stem cell transplantation; Hepatitis B virus | 公開日期: | 2009 | 卷: | 15 | 期: | 3 SUPP3 | 起(迄)頁: | 13-16 | 來源出版物: | Hong Kong Medical Journal | 摘要: | In Taiwan, haematopoietic stem cell transplantation (HSCT) has been used to treat patients with haematological diseases since 1983. Thereafter till 2007, there were 2537 patients who had undergone HSCT in more than 15 hospitals. Their diseases included acute myeloid leukaemia in 27.8% of cases, non-Hodgkin's lymphoma 23.3%, acute lymphoblastic leukaemia 12.8%, chronic myeloid leukaemia 11.9%, severe aplastic anaemia 8.7%, and multiple myeloma 4.1%. Most of the cases received myeloablative conditioning regimens. More than 15% of cases received non-myeloablative regimens, and the mean age of these cases was at least 10 years older than those who received myeloablative regimens. The types of graft included peripheral blood (60.4%) and bone marrow (32.0%). A total of 35% of patients received autologous grafts. Of 1557 allogeneic HSCT patients, 338 (21.7%) received grafts from unrelated donors. Cord blood transplantation has been successfully performed in paediatric patients with thalassaemia major and with a large body size, and adult patients. The incidence of acute graft-versus-host disease was relatively low in Taiwan. On the contrary, a relatively higher proportion of hepatitis B carrier in the recipients had led to a higher incidence of reactivation hepatitis, which was markedly decreased following lamivudine prophylaxis. In conclusion, HSCT has become a routine therapy for major medical centres in Taiwan. Our unique experiences in the past decades also contributed to the progress of HSCT. With the establishment of professional association and patient supportive groups, we hope we can fully improve our daily practice and clinical as well as basic research in HSCT. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-68549111026&partnerID=40&md5=5a36ba0dfcae270a4235fdd4b037f546 https://scholars.lib.ntu.edu.tw/handle/123456789/538760 |
ISSN: | 1024-2708 | SDG/關鍵字: | adult; allotransplantation; article; child; cord blood stem cell transplantation; ethnology; graft versus host reaction; hematopoietic stem cell transplantation; human; prevalence; register; statistics; Taiwan; acute graft versus host disease; acute lymphoblastic leukemia; acute myeloblastic leukemia; aplastic anemia; Article; bone graft; bone marrow; chronic myeloid leukemia; cytomegalovirus infection; disease registry; hematopoietic stem cell transplantation; hepatitis B; herpes zoster; lung tuberculosis; lymphoproliferative disease; multiple myeloma; myeloablative conditioning; nonhodgkin lymphoma; pregnancy; Taiwan; thalassemia major; Adult; Child; Cord Blood Stem Cell Transplantation; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Prevalence; Registries; Taiwan; Transplantation, Homologous; lamivudine; leukocyte antigen; membrane antigen |
顯示於: | 醫學系 |
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