https://scholars.lib.ntu.edu.tw/handle/123456789/539550
標題: | Waning population immunity to measles in Taiwan | 作者: | Chen C.-J. PING-ING LEE Hsieh Y.-C. Chen P.-Y. Ho Y.-H. Chang C.-J. DING-PING LIU Chang F.-Y. Chiu C.-H. Huang Y.-C. Lee C.-Y. Lin T.-Y. |
公開日期: | 2012 | 卷: | 30 | 期: | 47 | 起(迄)頁: | 6721-6727 | 來源出版物: | Vaccine | 摘要: | To evaluate the population immunity to measles in Taiwan where the coverage rate of the measles vaccine was >95% for more than a decade, anti-measles IgG was determined in 3552 Taiwanese volunteers in 2007. The overall seroprevalence was 74.7% (95% confidence interval [CI]: 73.3-76.1%). In subgroups aged 2-25 years, to whom at least 2 doses of measles-containing vaccine were given, there was a declining trend of seropositivity with age from 94.5% at 2 years to 50.6% at 21-25 years (p<0.0001). Age (odds ratio [OR]: 1.0464, 95% CI: 1.043-1.085) and male gender (OR: 1.466, 95% CI: 1.131-1.901) were independent factors predicting seronegative sera in this population. Seroprevalence was uniformly >95% in the older population (?35 years) who had not been immunized against measles. The waning vaccine-induced immunity may have impact on the control of measles in the future, especially when the vaccinated population becomes older. ? 2012. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84867483656&doi=10.1016%2fj.vaccine.2012.05.019&partnerID=40&md5=e2bac7db068ab47c1daf05676ed0224c https://scholars.lib.ntu.edu.tw/handle/123456789/539550 |
ISSN: | 0264-410X | DOI: | 10.1016/j.vaccine.2012.05.019 | SDG/關鍵字: | immunoglobulin G; measles vaccine; article; female; human; immunity; major clinical study; male; measles; population research; priority journal; seroprevalence; Taiwan; Adolescent; Adult; Age Factors; Aged; Antibodies, Viral; Child; Child, Preschool; Female; Humans; Immunity, Herd; Infant; Male; Measles; Measles Vaccine; Middle Aged; Seroepidemiologic Studies; Taiwan; Young Adult |
顯示於: | 醫學系 |
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