https://scholars.lib.ntu.edu.tw/handle/123456789/540121
標題: | Effect of menarche onset on the clinical course in females with chronic hepatitis B virus infection | 作者: | JIA-FENG WU Tsai W.-Y. YI-CHING TUNG HUEY-LING CHEN YEN-HSUAN NI HONG-YUAN HSU MEI-HWEI CHANG |
公開日期: | 2014 | 出版社: | Mosby Inc. | 卷: | 165 | 期: | 3 | 起(迄)頁: | 534-538 | 來源出版物: | Journal of Pediatrics | 摘要: | Objective To investigate the impact of menarche on the natural course of chronic hepatitis B virus (HBV) infection in women. Study design Young women who are positive for hepatitis B e antigen (HBeAg; n = 101) chronically infected with genotypes B and C HBV were recruited at a mean age of 4.57 ± 3.08 years, and a mean follow-up duration of 23.98 ± 3.77 years. Clinical data, including age at menarche, HBV genotypes, serum HBV viral loads, hepatitis B surface antigen (HBsAg) titers, and serial liver functional profiles were analyzed. Results Women with earlier onset of menarche had earlier spontaneous HBeAg seroconversion than others (hazard ratio, 2.0; P =.02) adjusting for HBV genotype and peak alanine aminotransferase levels before HBeAg seroconversion. The annual decrease in HBsAg titer from 15 to 20 years of age also was greater in the early menarche group compared with the late menarche group (0.11 ± 0.11 vs 0.05 ± 0.11 log10 IU/mL, P =.04). The baseline HBV viral load was also borderline low in female subjects with earlier menarche as compared with others (P =.06). Earlier menarche onset was associated with higher spontaneous HBeAg seroconversion, HBsAg seroclearance, and HBsAg seroconversion rate before 15 years of age in females with chronic HBV infection. Conclusions Earlier puberty-onset, indicated by menarche-onset, was associated with earlier spontaneous HBeAg seroconversion and greater rate of HBV clearance before 15 years of age in female subjects with chronic HBV infection. Copyright ? 2014 Elsevier Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84906794278&doi=10.1016%2fj.jpeds.2014.05.049&partnerID=40&md5=18ec12a85086c8e004b42a1d6fa7ca4c https://scholars.lib.ntu.edu.tw/handle/123456789/540121 |
ISSN: | 0022-3476 | DOI: | 10.1016/j.jpeds.2014.05.049 | SDG/關鍵字: | alanine aminotransferase; hepatitis B surface antigen; hepatitis B(e) antigen; hepatitis B surface antigen; hepatitis B(e) antigen; article; child; disease course; female; genotype; hepatitis B; Hepatitis B virus genotype B; Hepatitis B virus genotype C; human; liver function; major clinical study; menarche; preschool child; priority journal; seroconversion; virus load; adolescent; adult; blood; follow up; hepatitis B; immunology; retrospective study; young adult; Adolescent; Adult; Child; Child, Preschool; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Menarche; Retrospective Studies; Young Adult |
顯示於: | 醫學系 |
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