https://scholars.lib.ntu.edu.tw/handle/123456789/540131
Title: | β-Cell Autoantibodies and Their Function in Taiwanese Children With Type 1 Diabetes Mellitus | Authors: | YI-CHING TUNG Chen M.-H. CHENG-TING LEE Tsai W.-Y. |
Issue Date: | 2009 | Journal Volume: | 108 | Journal Issue: | 11 | Start page/Pages: | 856-861 | Source: | Journal of the Formosan Medical Association | Abstract: | Background/Purpose: To understand the importance of autoimmunity in the development of type 1 diabetes in Taiwanese children, we evaluated the presence of β-cell autoantibodies and their correlation with residual β-cell function. Methods: From 1989 to 2006, 157 Taiwanese children with newly diagnosed type 1 diabetes were enrolled in this study. We determined the presence of β-cell autoantibodies, such as glutamic acid decarboxylase autoantibodies (GADAs), insulinoma antigen 2 autoantibodies (IA-2As), and insulin autoantibodies (IAAs). A 6-minute glucagon test was also performed at diagnosis. Results: At diagnosis, 73% of children tested positive for GADAs, 76% for IA-2As and 21% for IAAs. Ninety-two percent of them had at least one of the β-cell autoantibodies detected. Positivity for IAAs was more frequent in patients younger than 5 years than in those older than 5 years (45% vs. 13%). Using multiple regression analysis, the presence of GADAs or IAAs, or age of onset of these patients was an independent factor for residual β-cell function. Younger patients and those with GADAs had less residual β-cell function at disease onset, whereas those with IAAs had more insulin reserve. Conclusion: Autoimmunity plays an important role in the pathogenesis of type 1 diabetes in Taiwanese children, and the presence of IAAs tends to be more common in younger children. ? 2009 Formosan Medical Association & Elsevier. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-71649089466&doi=10.1016%2fS0929-6646%2809%2960417-4&partnerID=40&md5=86129322ad5e127dd3883a7df02277a5 https://scholars.lib.ntu.edu.tw/handle/123456789/540131 |
ISSN: | 0929-6646 | DOI: | 10.1016/S0929-6646(09)60417-4 | SDG/Keyword: | autoantibody; C peptide; glucagon; glutamate decarboxylase 65 antibody; hemoglobin A1c; insulin; insulin antibody; insulinoma antigen 2 autoantibody; unclassified drug; adolescent; adult; age distribution; antibody detection; article; autoimmunity; child; female; human; immunopathogenesis; infant; insulin dependent diabetes mellitus; insulin release; major clinical study; male; multiple regression; onset age; pancreas islet beta cell; preschool child; school child; Adolescent; Age Factors; Autoantibodies; Child; Child, Preschool; Diabetes Mellitus, Type 1; Female; Humans; Infant; Insulin-Secreting Cells; Male |
Appears in Collections: | 醫學系 |
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