https://scholars.lib.ntu.edu.tw/handle/123456789/540139
標題: | Long-term outcome of hormonal status in Taiwanese children with Hashimoto's thyroiditis | 作者: | Wang S.-Y. YI-CHING TUNG Tsai W.-Y. Lee J.-S. Hsiao P.-H. |
關鍵字: | Hashimoto's thyroiditis thyroid function | 公開日期: | 2006 | 卷: | 165 | 期: | 7 | 起(迄)頁: | 481-483 | 來源出版物: | European Journal of Pediatrics | 摘要: | The objective of this prospective study was to evaluate both thyroid function in children with Hashimoto's thyroiditis and the necessity of lifetime thyroxine replacement therapy. A total of 47 patients with goiter and positive thyroid auto-antibodies participated in the study. Serum thyroxine and thyrotropin levels and titers of thyroid auto-antibodies were checked regularly throughout the follow-up period. At the beginning of the study, 25 patients were diagnosed as euthyroid, but at the end of the study, 22 patients initially diagnosed with euthyroidism remained euthyroid, while eight patients with subclinical hypothyroidism and three patients with overt hypothyroidism had become euthyroid. Thus, of the 22 patients with thyroid dysfunction at diagnosis, subclinical or overt, 11 became euthyroid during the follow-up period. The effect of thyroxine treatment on thyroid auto-antibody titers was not significant. Conclusion: Our data shows that Hashimoto's thyroiditis in children has a benign course and that thyroid function in one half of the patients with thyroid dysfunction at diagnosis reverts to normal. Careful follow-up of thyroid function is important in order to determine the necessity and timing of thyroxine replacement therapy. ? Springer-Verlag 2006. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33744483406&doi=10.1007%2fs00431-006-0112-5&partnerID=40&md5=dd7864bf2d100d7a2cebe5d204ce1d97 https://scholars.lib.ntu.edu.tw/handle/123456789/540139 |
ISSN: | 0340-6199 | DOI: | 10.1007/s00431-006-0112-5 | SDG/關鍵字: | liothyronine; microsome antibody; thyroglobulin antibody; thyroid antibody; thyrotropin; thyroxine; adolescent; antibody titer; article; child; clinical article; controlled study; disease course; female; follow up; Hashimoto disease; hormone substitution; human; long term care; male; priority journal; prospective study; Taiwan; thyroid function; thyrotropin blood level; thyroxine blood level; treatment outcome; Adolescent; Chi-Square Distribution; Child; Child, Preschool; Female; Hashimoto Disease; Humans; Male; Prospective Studies; Taiwan; Thyroid Function Tests; Thyroxine; Treatment Outcome |
顯示於: | 醫學系 |
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