https://scholars.lib.ntu.edu.tw/handle/123456789/540141
Title: | Adult height of patients with classical congenital adrenal hyperplasia | Authors: | YI-CHING TUNG Lee J.-S. WEN-YU TSAI Hsiao P.-H. |
Keywords: | Congenital adrenal hyperplasia; Growth and development; Height, body; Precocious puberty; Risk factors | Issue Date: | 2005 | Journal Volume: | 104 | Journal Issue: | 2 | Start page/Pages: | 133-136 | Source: | Journal of the Formosan Medical Association | Abstract: | Background and Purpose: Data on factors that affect the final height of patients with classical congenital adrenal hyperplasia (CAH) are limited. This study investigated the factors that can affect height outcome of patients with classical CAH. Methods: A retrospective study of 44 patients (16 males, 28 females) with classical CAH who had attained the adult height without gonadotropin-releasing hormone analog therapy was conducted. Adult height standard deviation scores (AHSDS) and target height standard deviation scores (THSDS) were determined. The impact of type, gender, control of disease activity or occurrence of precocious puberty on height was analyzed. Results: The difference between AHSDS and THSDS of the 44 patients was -0.7 ± 1.0 and was greatest in simple-virilizing males (-1.1 standard deviation score [SDS]). However, no significant differences in height outcomes were identified between genders and types. The differences between AHSDS and THSDS of patients with good control of disease activity or normal puberty were -0.3 SDS and -0.4 SDS, respectively, which were better height outcomes than those of the other groups (p < 0.05). Conclusions: Classical CAH can lead to reduced adult height. Good control of disease activity and the prevention of the occurrence of precocious puberty is important to achieving normal adult height outcome. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-20144371193&partnerID=40&md5=c4832d33ff738cc55c6d5ab6e2ba1e11 https://scholars.lib.ntu.edu.tw/handle/123456789/540141 |
ISSN: | 0929-6646 | SDG/Keyword: | article; bone age; clinical article; clinical feature; congenital adrenal hyperplasia; controlled study; data analysis; disease activity; female; height; human; male; precocious puberty; scoring system; adult; body height; pathophysiology; physiology; reference value; retrospective study; Adrenal Hyperplasia, Congenital; Adult; Body Height; Female; Humans; Male; Puberty, Precocious; Reference Values; Retrospective Studies |
Appears in Collections: | 醫學系 |
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