https://scholars.lib.ntu.edu.tw/handle/123456789/540560
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Chen, Yu-Chen | en_US |
dc.contributor.author | Chuang, Tzu-Yi | en_US |
dc.contributor.author | Liu, Chen-Wei | en_US |
dc.contributor.author | Liu, Chi-Wei | en_US |
dc.contributor.author | Lee, Tzu-Lin | en_US |
dc.contributor.author | Lai, Tsai-Chun | en_US |
dc.contributor.author | YUH-LIEN CHEN | en_US |
dc.creator | Chen, Yu-Chen;Chuang, Tzu-Yi;Liu, Chen-Wei;Liu, Chi-Wei;Lee, Tzu-Lin;Lai, Tsai-Chun;Yuh-Lien Chen | - |
dc.date.accessioned | 2021-01-13T08:21:20Z | - |
dc.date.available | 2021-01-13T08:21:20Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1743-8977 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/540560 | - |
dc.description.abstract | Particulate matters (PMs) in ambient air pollution are closely related to the incidence of respiratory diseases and decreased lung function. Our previous report demonstrated that PMs-induced oxidative stress increased the expression of proinflammatory intracellular adhesion molecule-1 (ICAM-1) through the IL-6/AKT/STAT3/NF-κB pathway in A549 cells. However, the role of O-PMs in epithelial-mesenchymal transition (EMT) development and pulmonary fibrosis and the related mechanisms have not been determined. The aim of this study was to investigate the effects of O-PMs on the pathogenesis of EMT and pulmonary fibrosis as well as the expression of ETS-1 and NF-κB p65, in vitro and in vivo. | en_US |
dc.language.iso | en | en_US |
dc.publisher | BMC | en_US |
dc.relation.ispartof | Particle and fibre toxicology | en_US |
dc.subject | EMT; ETS-1; Fibronectin; Particulate matters (PMs); Pulmonary fibrosis | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | fibronectin; n acetylprolylhistidylserylcysteinylasparagine amide; transcription factor Ets 1; transcription factor RelA; uvomorulin; vimentin; fibronectin; immunoglobulin enhancer binding protein; transcription factor RelA; A-549 cell line; animal experiment; animal model; animal tissue; Article; cell migration; controlled study; epithelial mesenchymal transition; epithelium cell; human; human cell; human tissue; in vitro study; in vivo study; lung fibrosis; lung parenchyma; male; mouse; nonhuman; particulate matter; pathogenesis; priority journal; protein expression; signal transduction; air pollutant; animal; epithelial mesenchymal transition; lung; lung alveolus epithelium cell; lung fibrosis; metabolism; particulate matter; pathophysiology; toxicity; A549 Cells; Air Pollutants; Alveolar Epithelial Cells; Animals; Epithelial-Mesenchymal Transition; Fibronectins; Humans; Lung; Mice; NF-kappa B; Particulate Matter; Pulmonary Fibrosis; Transcription Factor RelA | - |
dc.title | Particulate matters increase epithelial-mesenchymal transition and lung fibrosis through the ETS-1/NF-κB-dependent pathway in lung epithelial cells | en_US |
dc.identifier.doi | 10.1186/s12989-020-00373-z | - |
dc.identifier.pmid | 32799885 | - |
dc.identifier.isi | WOS:000561600100001 | - |
dc.relation.journalvolume | 17 | en_US |
dc.relation.journalissue | 1 | en_US |
item.languageiso639-1 | en | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Anatomy and Cell Biology | - |
crisitem.author.orcid | 0000-0002-6498-4008 | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 解剖學暨細胞生物學科所 |
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