https://scholars.lib.ntu.edu.tw/handle/123456789/540616
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | CHYI-FENG JAN | en_US |
dc.contributor.author | Liu T.-H. | en_US |
dc.contributor.author | Ho C.-H. | en_US |
dc.contributor.author | Chien Y.-C. | en_US |
dc.contributor.author | CHE-JUI CHANG | en_US |
dc.contributor.author | FEI-RAN GUO | en_US |
dc.contributor.author | KUO-CHIN HUANG | en_US |
dc.date.accessioned | 2021-01-14T03:08:40Z | - |
dc.date.available | 2021-01-14T03:08:40Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 0263-2136 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080844412&doi=10.1093%2ffampra%2fcmz039&partnerID=40&md5=c0249cc6cf7b510b35140de81ec3541e | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/540616 | - |
dc.description.abstract | Objectives: To determine the required hepatitis B vaccine doses for subjects who were seronegative for three hepatitis B seromarkers during their youth who wish to have seroprotective antibodies against the hepatitis B surface antigen (anti-HBs). Methods: We conducted a retrospective cohort study. From 2012 to 2015, graduate school students born after 1986 who were seronegative for three hepatitis B virus seromarkers at college entrance (n = 1037) were recruited. Four groups of subjects received zero to three doses of a hepatitis B vaccine booster at their free willingness, and their anti-HBs titre were measured at their graduate school entrance. Very low and extremely low antibody titres against the hepatitis B surface antigen were elucidated by graphic inference to determine the required booster dose cut-off value for seropositivity after revaccination. Results: The anti-HBs seropositive rates in the four groups of subjects receiving the hepatitis B booster vaccine(s) were 17.7%, 52.1%, 78.6% and 90.9% for those receiving zero, one, two and three doses, respectively. In subjects with very low antibody titres against the hepatitis B surface antigen after one dose of the vaccine booster and subjects with an extremely low titre after two doses of the booster, the seropositive rates reached 95% at the cut-off value of 3 mIU/ml. Conclusion: A seropositive rate of at least 95% can be reached by the administration of two hepatitis B booster doses to youths with extremely low antibody titres against the hepatitis B surface antigen (<3 mIU/ml) and administering one dose to those with very low titres (3-10 mIU/ml) at college. ? 2019 The Author(s) 2019. Published by Oxford University Press. | - |
dc.publisher | Oxford University Press | - |
dc.relation.ispartof | Family Practice | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | hepatitis B antibody; hepatitis B surface antigen; recombinant hepatitis B vaccine; hepatitis B antibody; hepatitis B surface antigen; hepatitis B vaccine; adult; antibody titer; Article; cohort analysis; college student; controlled study; dose response; female; graduate student; health center; hepatitis B; Hepatitis B virus; human; male; retrospective study; revaccination; Taiwan; university hospital; adolescent; hepatitis B; immunology; procedures; secondary immunization; young adult; Adolescent; Adult; Cohort Studies; Female; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Humans; Immunization, Secondary; Male; Retrospective Studies; Taiwan; Young Adult | - |
dc.title | Doses of hepatitis B revaccination needed for the seronegative youths to be seropositive to antibody against hepatitis B surface antigen | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1093/fampra/cmz039 | - |
dc.identifier.pmid | 31375819 | - |
dc.identifier.scopus | 2-s2.0-85080844412 | - |
dc.relation.pages | 30-35 | - |
dc.relation.journalvolume | 37 | - |
dc.relation.journalissue | 1 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Family Medicine-NTUH | - |
crisitem.author.dept | Family Medicine | - |
crisitem.author.dept | Referral Management Center | - |
crisitem.author.dept | Family Medicine-NTUHHC | - |
crisitem.author.dept | Family Medicine-NTUH | - |
crisitem.author.dept | Family Medicine | - |
crisitem.author.dept | Family Medicine | - |
crisitem.author.dept | Family Medicine-NTUH | - |
crisitem.author.dept | Health Behaviors and Community Sciences | - |
crisitem.author.dept | Psychology | - |
crisitem.author.orcid | 0000-0003-2893-2187 | - |
crisitem.author.orcid | 0000-0001-8939-8497 | - |
crisitem.author.orcid | 0000-0003-0671-9529 | - |
crisitem.author.orcid | 0000-0002-6029-5520 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Science | - |
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