https://scholars.lib.ntu.edu.tw/handle/123456789/540706
標題: | The risky body mass index ranges for significant hepatitis B viral load: A campus-based study | 作者: | CHIEN-HSIEH CHIANG Lai J.-S. JIN-CHUAN SHEU Yen L.-L. CHUN-JEN LIU KUO-CHIN HUANG |
公開日期: | 2012 | 卷: | 6 | 期: | 1 | 起(迄)頁: | e31-e38 | 來源出版物: | Obesity Research and Clinical Practice | 摘要: | Significant hepatitis B viral load (?10,000 copies/mL) was established to increase risk of advanced liver diseases. The aim of this study was to explore the metabolic risk factors for significant hepatitis B viral load. A campus-based cohort consisting of 146 participants of chronic hepatitis B virus (HBV) infection in Northern Taiwan was investigated in 2009. Clinical profiles including serum levels of deoxyribonucleic acid of hepatitis B virus (HBV DNA) were collected. Hepatitis B e antigen (HBeAg) serostatus, high alanine aminotransferase level, body mass index (BMI) ranges, and insulin resistance were related to significant HBV DNA levels in univariate analysis. Compared to individuals with BMI 23-24.9 kg/m 2 in multivariate analysis, those with BMI ?25 kg/m 2 (OR = 3.86, 95% CI = 1.38-10.8, P = 0.010) and those with BMI <23 kg/m 2 (OR = 4.47, 95% CI = 1.32-15.2, P = 0.016) were at higher risk for significant HBV DNA levels. This phenomenon was also manifest in HBeAg seronegatives, who contributed to a majority of significant viral load in our study. Furthermore, insulin resistance and BMI ?25 kg/m 2 had positive additive effects on significant HBV DNA levels (adjusted OR = 9.34, 95% CI = 1.74-50.3, P = 0.009). In conclusion, having certain BMI ranges (BMI ?25 kg/m 2 or BMI <23 kg/m 2) could be a risk factor of significant HBV DNA levels. ? 2011 Published by Elsevier Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84856105973&doi=10.1016%2fj.orcp.2011.04.005&partnerID=40&md5=9cf146286f80c31e2156e896ce12d1c3 https://scholars.lib.ntu.edu.tw/handle/123456789/540706 |
ISSN: | 1871-403X | DOI: | 10.1016/j.orcp.2011.04.005 | SDG/關鍵字: | alanine aminotransferase; C reactive protein; hepatitis B(e) antigen; high density lipoprotein cholesterol; insulin; low density lipoprotein cholesterol; triacylglycerol; virus DNA; adult; alanine aminotransferase blood level; article; body mass; female; hepatitis B; Hepatitis B virus; human; hypertension; insulin resistance; major clinical study; male; priority journal; risk factor; triacylglycerol blood level; virus load; waist circumference; Hepatitis B virus |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。