https://scholars.lib.ntu.edu.tw/handle/123456789/540792
標題: | A population-based study investigating the association between metabolic syndrome and Hepatitis B/C infection (Keelung Community-based Integrated Screening Study No. 10) | 作者: | CHYI-FENG JAN Chen C.-J. Chiu Y.-H. Chen L.-S. Wu H.-M. Huang C.-C. Yen M.-F. Chen, Tony Hsiu Hsi |
關鍵字: | Hepatitis B; Hepatitis C; Metabolic syndrome; Screening | 公開日期: | 2006 | 卷: | 30 | 期: | 5 | 起(迄)頁: | 794-799 | 來源出版物: | International Journal of Obesity | 摘要: | Objectives: We aimed to assess the association between metabolic syndrome (MS) and hepatitis B/C virus infection using a large population-based study. Design and methods: A population-based cross-sectional study design was adopted with a total of 53 528 subjects being enrolled from the integrated multiple diseases screening program in Keelung, Taiwan. Evidence of past hepatitis B/C infection, acquired during childhood or as a young adult, was identified during the two-stage liver cancer screening part of the process. Information on biochemical markers and anthropometric measures related to MS, such as fasting blood sugar, triglyceride and high-density lipoprotein (HDL), abdominal circumference and blood pressure (BP), were collected routinely while screening for hypertension, type 2 diabetes, and hyperlipidemia. Logistic regression was used to estimate odds ratios and related 95% confidence intervals for the associations between MS and hepatitis B/C infection. Results: High blood pressure (SBP ? 135 mmHg or DBP ? 85 mmHg) (adjusted odd ratio: 0.89 (0.83-0.94)) and high triglyceride (? 150 mg/dl) (adjusted odds ratio: 0.65 (0.60-0.69)) were, after adjusting for gender and age, inversely associated with being HBsAg positive (P < 0.05). The likelihood of developing MS was lower in the HBsAg positive than the HBsAg negative (adjusted odds ratio: 0.84 (0.76-0.93)). A positive association between being anti-HCV positive and having low serum HDL (male < 40 mg/dl, female < 50 mg/dl) was also noted (adjusted odds ratio: 1.61 (1.37-1.88) after controlling for gender and age). High triglyceride was inversely associated with being anti-HCV positive (adjusted odds ratio: 0.63 (0.55-0.71). Conclusions: There is an inverse association between MS and hepatitis B virus infection whereas the association was heterogeneous for HCV infection with a positive association with abnormal serum HDL but an inverse association with hypertriglyceridemia. ? 2006 Nature Publishing Group All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33646367660&doi=10.1038%2fsj.ijo.0803204&partnerID=40&md5=edc0adc62e78194b7ca03055105deac4 https://scholars.lib.ntu.edu.tw/handle/123456789/540792 |
ISSN: | 0307-0565 | DOI: | 10.1038/sj.ijo.0803204 | SDG/關鍵字: | biochemical marker; glucose; hepatitis B surface antigen; high density lipoprotein; triacylglycerol; abdomen; adult; age; aged; anthropometry; article; blood pressure; cancer staging; controlled study; disease association; female; gender; glucose blood level; hepatitis B; hepatitis C; human; hyperlipidemia; hypertension; hypertriglyceridemia; lipoprotein blood level; liver cancer; major clinical study; male; metabolic syndrome X; non insulin dependent diabetes mellitus; population research; priority journal; screening; Taiwan; triacylglycerol blood level; Adult; Aged; Epidemiologic Methods; Female; Hepacivirus; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis C; Hepatitis, Chronic; Humans; Male; Metabolic Syndrome X; Middle Aged; Taiwan; Hepatitis B virus; Hepatitis C virus |
顯示於: | 醫學系 |
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