https://scholars.lib.ntu.edu.tw/handle/123456789/540973
DC Field | Value | Language |
---|---|---|
dc.contributor.author | JYH-MING LIOU | en_US |
dc.contributor.author | Chang C.-Y. | en_US |
dc.contributor.author | Chen M.-J. | en_US |
dc.contributor.author | CHIEH-CHANG CHEN | en_US |
dc.contributor.author | YU-JEN FANG | en_US |
dc.contributor.author | Lee J.-Y. | en_US |
dc.contributor.author | Wu J.-Y. | en_US |
dc.contributor.author | Luo J.-C. | en_US |
dc.contributor.author | Liou T.-C. | en_US |
dc.contributor.author | Chang W.-H. | en_US |
dc.contributor.author | Tseng C.-H. | en_US |
dc.contributor.author | Wu C.-Y. | en_US |
dc.contributor.author | Yang T.-H. | en_US |
dc.contributor.author | Chang C.-C. | en_US |
dc.contributor.author | HSIU-PO WANG | en_US |
dc.contributor.author | Sheu B.-S. | en_US |
dc.contributor.author | Lin J.-T. | en_US |
dc.contributor.author | Bair M.-J. | en_US |
dc.contributor.author | MING-SHIANG WU | en_US |
dc.contributor.author | Tai C.-M. | en_US |
dc.contributor.author | Lee C.-T. | en_US |
dc.contributor.author | Wang W.-L. | en_US |
dc.contributor.author | YI-CHIA LEE | en_US |
dc.contributor.author | Wang Y.-C. | en_US |
dc.contributor.author | Taiwan Gastrointestinal Disease | en_US |
dc.contributor.author | Helicobacter Consortium | en_US |
dc.date.accessioned | 2021-01-15T03:46:42Z | - |
dc.date.available | 2021-01-15T03:46:42Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84929096058&doi=10.1371%2fjournal.pone.0124199&partnerID=40&md5=9d4e0e848b31164fa391f6f11daafc39 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/540973 | - |
dc.description.abstract | Objective: The Taiwan Government issued a policy to restrict antimicrobial usage since 2001. We aimed to assess the changes in the antibiotic consumption and the primary resistance of H. pylori after this policy and the impact of virulence factors on resistance. Methods: The defined daily dose (DDD) of antibiotics was analyzed using the Taiwan National Health Insurance (NHI) research database. H. pylori strains isolated from treatment na?ve (N=1395) and failure from prior eradication therapies (N=360) from 9 hospitals between 2000 and 2012 were used for analysis. The minimum inhibitory concentration was determined by agar dilution test. Genotyping for CagA and VacA was determined by PCR method. Results: The DDD per 1000 persons per day of macrolides reduced from 1.12 in 1997 to 0.19 in 2008, whereas that of fluoroquinolones increased from 0.12 in 1997 to 0.35 in 2008. The primary resistance of amoxicillin, clarithromycin, metronidazole, and tetracycline remained as low as 2.2%, 7.9%, 23.7%, and 1.9% respectively. However, the primary levofloxacin resistance rose from 4.9% in 2000-2007 to 8.3% in 2008-2010 and 13.4% in 2011-2012 (p=0.001). The primary resistance of metronidazole was higher in females than males (33.1% vs. 18.8%, p p[ampi]lt;0.001), which was probably attributed to the higher consumption of nitroimidazole. Neither CagA nor VacA was associated with antibiotic resistance. Conclusions: The low primary clarithromycin and metronidazole resistance of H. pylori in Taiwan mightbe attributed to the reduced consumption of macrolides and nitroimidazole after the national policy to restrict antimicrobial usage. Yet, further strategies are needed to restrict the consumption of fluoroquinolones in the face of rising levofloxacin resistance. ? 2015 Liou et al. | - |
dc.publisher | Public Library of Science | - |
dc.relation.ispartof | PLoS ONE | - |
dc.subject.other | amoxicillin; clarithromycin; levofloxacin; metronidazole; nitroimidazole; tetracycline; virulence factor; amoxicillin; antiinfective agent; clarithromycin; metronidazole; tetracycline; virulence factor; adult; antibiotic resistance; antibiotic therapy; Article; bacterium isolation; CagA gene; controlled study; drug use; eradication therapy; female; gene; genotype; health care policy; Helicobacter pylori; human; major clinical study; male; minimum inhibitory concentration; nonhuman; polymerase chain reaction; sex difference; Taiwan; VacA gene; drug effects; genetics; growth, development and aging; Helicobacter Infections; Helicobacter pylori; Helicobacter pylori; Amoxicillin; Anti-Bacterial Agents; Clarithromycin; Female; Genotype; Helicobacter Infections; Helicobacter pylori; Humans; Male; Metronidazole; Taiwan; Tetracycline; Virulence Factors | - |
dc.subject.other | [SDGs]SDG3 | - |
dc.title | The primary resistance of Helicobacter pylori in Taiwan after the national policy to restrict antibiotic consumption and its relation to virulence factors - A nationwide study | en_US |
dc.type | journal article | - |
dc.identifier.doi | 10.1371/journal.pone.0124199 | - |
dc.identifier.pmid | 25942450 | - |
dc.identifier.scopus | 2-s2.0-84929096058 | - |
dc.relation.journalvolume | 10 | - |
dc.relation.journalissue | 5 | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUHYL | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-7945-5408 | - |
crisitem.author.orcid | 0000-0003-2953-210X | - |
crisitem.author.orcid | 0000-0002-7741-9315 | - |
crisitem.author.orcid | 0000-0002-1940-6428 | - |
crisitem.author.orcid | 0000-0002-8160-1216 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital Yun-Lin Branch | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
Appears in Collections: | 醫學系 |
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