https://scholars.lib.ntu.edu.tw/handle/123456789/540975
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | WEI-CHIH LIAO | en_US |
dc.contributor.author | YU-KANG TU | en_US |
dc.contributor.author | MING-SHIANG WU | en_US |
dc.contributor.author | Lin J.-T. | en_US |
dc.contributor.author | HSIU-PO WANG | en_US |
dc.contributor.author | KUO-LIONG CHIEN | en_US |
dc.date.accessioned | 2021-01-15T03:46:43Z | - |
dc.date.available | 2021-01-15T03:46:43Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0959-8146 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84930220817&doi=10.1136%2fbmj.g7371&partnerID=40&md5=fd6248d904dca37e98020bd25273cde7 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/540975 | - |
dc.description.abstract | Objective: To evaluate potential linear and non-linear dose-response relations between blood glucose and risk of pancreatic cancer. Design: Systematic review and dose-response meta-analysis of prospective observational studies. Data sources: Search of PubMed, Scopus, and related reviews before 30 November 2013 without language restriction. Eligibility criteria: Prospective studies evaluating the association between blood glucose concentration and pancreatic cancer. Retrospective and cross sectional studies excluded to avoid reverse causality. Data extraction and synthesis: Two reviewers independently extracted relevant information and assessed study quality with the Newcastle-Ottawa scale. Random effects dose-response meta-analysis was conducted to assess potential linear and non-linear dose-response relations. Results: Nine studies were included for analysis, with a total of 2408 patients with pancreatic cancer. There was a strong linear dose-response association between fasting blood glucose concentration and the rate of pancreatic cancer across the range of prediabetes and diabetes. No non-linear association was detected. The pooled rate ratio of pancreatic cancer per 0.56 mmol/L (10 mg/dL) increase in fasting blood glucose was 1.14 (95% confidence interval 1.06 to 1.22; P<0.001) without significant heterogeneity. Sensitivity analysis excluding blood glucose categories in the range of diabetes showed similar results (pooled rate ratio per 0.56 mmol/L increase in fasting blood glucose was 1.15, 95% confidence interval 1.05 to 1.27; P=0.003), strengthening the association between prediabetes and pancreatic cancer. Conclusions: Every 0.56 mmol/L increase in fasting blood glucose is associated with a 14% increase in the rate of pancreatic cancer. As prediabetes can be improved or even reversed through lifestyle changes, early detection of prediabetes coupled with lifestyle changes could represent a viable strategy to curb the increasing incidence of pancreatic cancer. | - |
dc.publisher | BMJ Publishing Group | - |
dc.relation.ispartof | BMJ (Online) | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | glucose; hemoglobin A1c; glucose blood level; Article; cancer mortality; cancer prevention; cancer risk; diabetes mellitus; disease association; dose response; glucose blood level; human; impaired glucose tolerance; incidence; lifestyle modification; observational study; pancreas cancer; priority journal; prospective study; risk factor; sex difference; systematic review; analysis; biometry; blood; complication; early diagnosis; glucose blood level; health behavior; hyperglycemia; meta analysis; Pancreatic Neoplasms; Prediabetic State; psychology; statistics; Biometry; Blood Glucose; Early Diagnosis; Health Behavior; Humans; Hyperglycemia; Observational Studies as Topic; Pancreatic Neoplasms; Prediabetic State; Risk Factors; Statistics as Topic | - |
dc.title | Blood glucose concentration and risk of pancreatic cancer: Systematic review and dose-response meta-analysis | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1136/bmj.g7371 | - |
dc.identifier.pmid | 25556126 | - |
dc.identifier.scopus | 2-s2.0-84930220817 | - |
dc.relation.journalvolume | 349 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Integrated Diagnostics and Therapeutics-NTUH | - |
crisitem.author.dept | Institute of Health Data Analytics and Statistics | - |
crisitem.author.dept | Master of Public Health Degree Program | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Public Health | - |
crisitem.author.orcid | 0000-0001-5362-6953 | - |
crisitem.author.orcid | 0000-0002-2461-474X | - |
crisitem.author.orcid | 0000-0002-1940-6428 | - |
crisitem.author.orcid | 0000-0002-7741-9315 | - |
crisitem.author.orcid | 0000-0003-4979-8351 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
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