https://scholars.lib.ntu.edu.tw/handle/123456789/542060
標題: | Smoking behavior and survival outcomes in bladder cancer patients | 作者: | Chu W.-C. CHUNG-HSIN CHEN |
關鍵字: | Bladder urothelial carcinoma; smoking; survival | 公開日期: | 2020 | 出版社: | Wolters Kluwer Medknow Publications | 卷: | 31 | 期: | 3 | 起(迄)頁: | 123-130 | 來源出版物: | Urological Science | 摘要: | Purpose: The purpose of this study was to compare the survival outcomes of bladder cancer patients with different smoking behaviors. Materials and Methods: Between January 2011 and December 2014, a total of 565 bladder cancer patients were included from one institute retrospectively. Regarding smoking behavior, among these patients, 337 were nonsmokers, 52 were 'quitters' (patients who had quit smoking ?10 years ago), 54 were ex-smokers (patients who had quit smoking <10 years ago), and 117 were current smokers. We compared the clinicopathological characteristics and survival outcomes among these four groups. Results: In this cohort, the 3-year overall survival (OS) (95% confidence interval [CI]) of the nonsmoker, quitter, ex-smoker, and current smoker groups were 75.6% (95% CI: 72.9%-78.3%), 67.4% (95% CI: 59.8%-75%), 84.1% (95% CI: 78.9%-89.3%), and 83.2% (95% CI: 79.3%-87.1%), respectively. Nonsmoker patients included a higher number of females, and quitters were older than the patients in the other groups. Larger tumors in quitters and higher clinical stages in ex-smokers were observed more frequently than in the patients of the other groups. Compared with nonsmokers, quitters, and ex-smokers, current smokers had no impact on OS (P = 0.541, 0.406, and 0.175, respectively) nor on cancer-specific survival (CSS) (P = 0.631, 0.388, and 0.193, respectively). Higher diagnostic age, being underweight, larger tumor sizes, and higher clinical stages were independent factors predicting OS. Conclusion: Smoking behavior seemed to not directly contribute to the deterioration of overall or CSS duration in patients with bladder cancer. ? 2020 Wolters Kluwer Medknow Publications. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089663901&doi=10.4103%2fUROS.UROS_95_19&partnerID=40&md5=1c84cdd4257fe6f24710c56ea053588e https://scholars.lib.ntu.edu.tw/handle/123456789/542060 |
ISSN: | 1879-5226 | DOI: | 10.4103/UROS.UROS_95_19 | SDG/關鍵字: | adult; aged; Article; bladder cancer; cancer specific survival; cancer staging; cancer survival; clinical assessment; cohort analysis; comparative study; controlled study; current smoker; ex-smoker; female; histopathology; human; major clinical study; male; mortality rate; non-smoker; outcome assessment; overall survival; priority journal; retrospective study; size; smoking; smoking cessation; underweight |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。