https://scholars.lib.ntu.edu.tw/handle/123456789/544018
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | SHUO-MENG WANG | en_US |
dc.contributor.author | Lai M.-N. | en_US |
dc.contributor.author | Wei A. | en_US |
dc.contributor.author | Chen Y.-Y. | en_US |
dc.contributor.author | YEONG-SHIAU PU | en_US |
dc.contributor.author | PAU-CHUNG CHEN | en_US |
dc.contributor.author | Wang J.-D. | en_US |
dc.creator | Shuo-Meng Wang;Lai M.-N.;Wei A.;Chen Y.-Y.;Pu Y.-S.;Chen P.-C.;Wang J.-D. | - |
dc.date.accessioned | 2021-02-01T07:30:30Z | - |
dc.date.available | 2021-02-01T07:30:30Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84929507677&doi=10.1371%2fjournal.pone.0105218&partnerID=40&md5=1a448148c6aa524c8828b5eada7bd75c | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/544018 | - |
dc.description.abstract | Introduction: Both end-stage renal disease (ESRD) and urothelial cancer (UC) are associated with the consumption of Chinese herbal products containing aristolochic acid (AA) by the general population. The objective of this study was to determine the risk of UC associated with AA-related Chinese herbal products among ESRD patients. Methods: We conducted a cohort study using the National Health Insurance reimbursement database to enroll all ESRD patients in Taiwan from 1998-2002. Cox regression models were constructed and hazard ratios and confidence intervals were estimated after controlling for potential confounders, including age, sex, residence in region with endemic black foot disease, urinary tract infection, and use of non-steroidal anti-inflammatory drugs and acetaminophen. Results: A total of 38,995 ESRD patients were included in the final analysis, and 320 patients developed UC after ESRD. Having been prescribed Mu Tong that was adulterated with Guan Mu Tong (Aristolochia manshuriensis) before 2004, or an estimated consumption of more than 1-100 mg of aristolochic acid, were both associated with an increased risk of UC in the multivariable analyses. Analgesic consumption of more than 150 pills was also associated with an increased risk of UC, although there was little correlation between the two risk factors. Conclusion: Consumption of aristolochic acid-related Chinese herbal products was associated with an increased risk of developing UC in ESRD patients. Regular follow-up screening for UC in ESRD patients who have consumed Chinese herbal products is thus necessary. ? 2014 Wang et al. | - |
dc.relation.ispartof | PLoS ONE | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | aristolochic acid; herbaceous agent; nonsteroid antiinflammatory agent; paracetamol; aristolochic acid; aristolochic acid I; herbaceous agent; adult; age; aged; article; blackfoot disease; cancer risk; cancer susceptibility; cohort analysis; data base; disease association; drug use; end stage renal disease; endemic disease; female; gender; human; major clinical study; male; national health insurance; prescription; reimbursement; residential area; risk assessment; Taiwan; urinary tract cancer; urinary tract infection; urothelial cancer; chemically induced; complication; incidence; Kidney Failure, Chronic; middle aged; risk factor; Urologic Neoplasms; very elderly; Aged; Aged, 80 and over; Aristolochic Acids; Cohort Studies; Drugs, Chinese Herbal; Female; Humans; Incidence; Kidney Failure, Chronic; Male; Middle Aged; Risk Factors; Taiwan; Urologic Neoplasms | - |
dc.title | Increased risk of urinary tract cancer in ESRD patients associated with usage of Chinese herbal products suspected of containing aristolochic acid | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1371/journal.pone.0105218 | - |
dc.identifier.pmid | 25170766 | - |
dc.identifier.scopus | 2-s2.0-84929507677 | - |
dc.relation.pages | e105218 | - |
dc.relation.journalvolume | 9 | - |
dc.relation.journalissue | 8 | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology-NTUHHC | - |
crisitem.author.dept | Urology-NTUHBH | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Surgical Oncology-NTUCC | - |
crisitem.author.dept | Urology-NTUHBP | - |
crisitem.author.dept | Institute of Environmental and Occupational Health Sciences | - |
crisitem.author.dept | Environmental and Occupational Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-2090-1757 | - |
crisitem.author.orcid | 0000-0002-2859-3966 | - |
crisitem.author.orcid | 0000-0002-6242-5974 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital Bei-Hu Branch | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | NTU BioMedical Park Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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