https://scholars.lib.ntu.edu.tw/handle/123456789/544450
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lin K.-W. | en_US |
dc.contributor.author | Huang A.-M. | en_US |
dc.contributor.author | Tu H.-Y. | en_US |
dc.contributor.author | Weng J.-R.U. | en_US |
dc.contributor.author | Hour T.-C. | en_US |
dc.contributor.author | Wei B.-L. | en_US |
dc.contributor.author | Yang S.-C. | en_US |
dc.contributor.author | Wang J.-P. | en_US |
dc.contributor.author | YEONG-SHIAU PU | en_US |
dc.contributor.author | Lin C.-N. | en_US |
dc.creator | Lin K.-W.;Huang A.-M.;Tu H.-Y.;Weng J.-R.U.;Hour T.-C.;Wei B.-L.;Yang S.-C.;Wang J.-P.;Yeong-Shiau Pu;Lin C.-N. | - |
dc.date.accessioned | 2021-02-02T00:46:46Z | - |
dc.date.available | 2021-02-02T00:46:46Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-70349912048&doi=10.1021%2fjf900935n&partnerID=40&md5=dc6b6d24e6a7dfb515dc1547a03c62ba | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/544450 | - |
dc.description.abstract | Phloroglucinols, garcinielliptones HA-HE (1-5), and C (6) were studied in vitro for their inhibitory effects on chemical mediators released from mast cells, neutrophils, and macrophages. Compound 6 revealed significant inhibitory effect on release of lysozyme from rat neutrophils stimulated with formyl-Met-Leu-Phe (fMLP)/cytochalasin B (CB). Compounds 3, 4, and 6 showed significant inhibitory effects on superoxide anion generation in rat neutrophils stimulated with (fMLP)/(CB), while compounds 1 and 5 revealed inhibitory effects on tumor necrosis factor-α (TNF-α) formation in macrophages stimulated with lipopolysaccharide (LPS). Compounds 1 and 3-6 showed inhibitory effects on xanthine oxidase (XO) and could inhibit the DNA breakage caused by O2-.. Treatment of NTUB1 with 2 to 60 μM compound 3 and 5 μM cisplatin and SV-HUC1 with 9 to 60 μM 3 and 5 μM cisplatin, respectively, resulted in an increase of viability of cells. These results indicated that compounds 1 and 3-6 showed anti-inflammatory effects and antioxidant activities. Compound 3 mediates through the suppression of XO activity and reduction of reactive oxygen species (ROS), and protection of subsequent cell death. ? 2009 American Chemical Society. | - |
dc.relation.ispartof | Journal of Agricultural and Food Chemistry | - |
dc.subject | Antioxidant; Garcinielliptones ha-he and anti-inflammatory; NTUB1; Phloroglucinol; SV-HUC1 | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | antiinflammatory agent; antioxidant; cisplatin; enzyme inhibitor; garcinielliptone; phloroglucinol; reactive oxygen metabolite; triterpene; xanthine oxidase; animal; article; bladder tumor; cell death; chemistry; drug antagonism; drug effect; enzymology; Garcinia; human; immunology; macrophage; mast cell; neutrophil; pathology; rat; tumor cell line; urothelium; Animals; Anti-Inflammatory Agents; Antioxidants; Cell Death; Cell Line, Tumor; Cisplatin; Enzyme Inhibitors; Garcinia; Humans; Macrophages; Mast Cells; Neutrophils; Phloroglucinol; Rats; Reactive Oxygen Species; Triterpenes; Urinary Bladder Neoplasms; Urothelium; Xanthine Oxidase; Rattus | - |
dc.title | Phloroglucinols Inhibit Chemical Mediators and Xanthine Oxidase, and Protect Cisplatin-Induced Cell Death by Reducing Reactive Oxygen Species in Normal Human Urothelial and Bladder Cancer Cells | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1021/jf900935n | - |
dc.identifier.pmid | 19754119 | - |
dc.identifier.scopus | 2-s2.0-70349912048 | - |
dc.relation.pages | 8782-8787 | - |
dc.relation.journalvolume | 57 | - |
dc.relation.journalissue | 19 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
crisitem.author.dept | Urology | - |
crisitem.author.dept | Urology-NTUH | - |
crisitem.author.dept | Surgical Oncology-NTUCC | - |
crisitem.author.dept | Urology-NTUHBP | - |
crisitem.author.orcid | 0000-0002-2859-3966 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Cancer Center (NTUCC) | - |
crisitem.author.parentorg | NTU BioMedical Park Hospital | - |
顯示於: | 醫學系 |
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