https://scholars.lib.ntu.edu.tw/handle/123456789/545283
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Yang N.-Y. | en_US |
dc.contributor.author | CHEN-YING WANG | en_US |
dc.contributor.author | Chyuan I.-T. | en_US |
dc.contributor.author | KING-JEAN WU | en_US |
dc.contributor.author | YU-KANG TU | en_US |
dc.contributor.author | Chang C.-W. | en_US |
dc.contributor.author | PING-NING HSU | en_US |
dc.contributor.author | YEN-PING KUO | en_US |
dc.contributor.author | YI-WEN CHEN | en_US |
dc.date.accessioned | 2021-02-02T02:47:55Z | - |
dc.date.available | 2021-02-02T02:47:55Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0929-6646 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85034768720&doi=10.1016%2fj.jfma.2017.11.006&partnerID=40&md5=84a2d60293a640ed01a4a5487b13791c | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/545283 | - |
dc.description.abstract | Background/Purpose: Chronic periodontitis (CP) and rheumatoid arthritis (RA) are the most common chronic inflammatory diseases and their immunopathogenesis is similar. The aim of this study was to evaluate the effect of non-surgical periodontal treatment on the serum levels of RA-related inflammatory markers in patients with chronic periodontitis. Methods: Thirty-one Taiwanese adults with CP were included. Demographics and periodontal parameters, including probing depth, clinical attachment level, and number of remaining teeth in the oral cavity, were recorded. All subjects received non-surgical periodontal treatment such as scaling and subgingival root planing. Serum samples were collected before and after the treatment. Serum levels of anti-citrullinated protein antibodies (ACPA), rheumatoid factor, tumor necrosis factor-α (TNF-α), C-reactive protein, interleukin-1β (IL-1β), and Interleukin-6 (IL-6) were measured using an enzyme-linked immunosorbent assay. Results: Non-surgical periodontal treatment significantly reduced the serum ACPA (p = 0.015) and TNF-α levels (p = 0.026) in CP patients, particularly in patients with generalized CP. Furthermore, there was a significant and positive correlation between the number of extracted teeth and the reduction in the serum ACPA (p = 0.05) and IL-1β levels (p = 0.029) after non-surgical periodontal treatment. Conclusion: Non-surgical periodontal therapy may aid in the control of RA-related inflammatory markers in patients with CP. A large-scale study with well-defined populations is needed to clarify the benefit of non-surgical periodontal therapy. ? 2017 | en_US |
dc.publisher | Elsevier B.V. | en_US |
dc.relation.ispartof | Journal of the Formosan Medical Association | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | C reactive protein; cyclic citrullinated peptide antibody; interleukin 1beta; interleukin 6; rheumatoid factor; tumor necrosis factor; biological marker; cyclic citrullinated peptide antibody; IL1B protein, human; interleukin 1beta; tumor necrosis factor; adult; antibody blood level; Article; chronic periodontitis; clinical article; clinical attachment level; dental parameters; dental scaling; enzyme linked immunosorbent assay; female; human; inflammation; male; middle aged; mouth cavity; mouth hygiene; periodontal examination; plaque index; probing depth; protein blood level; rheumatoid arthritis; root planing; Taiwanese; blood; chronic periodontitis; dental curettage; regression analysis; rheumatoid arthritis; Adult; Anti-Citrullinated Protein Antibodies; Arthritis, Rheumatoid; Biomarkers; Chronic Periodontitis; Dental Scaling; Female; Humans; Interleukin-1beta; Male; Middle Aged; Regression Analysis; Subgingival Curettage; Tumor Necrosis Factor-alpha | - |
dc.title | Significant association of rheumatoid arthritis-related inflammatory markers with non-surgical periodontal therapy | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jfma.2017.11.006 | - |
dc.identifier.pmid | 29174174 | - |
dc.identifier.scopus | 2-s2.0-85034768720 | - |
dc.relation.pages | 1003-1010 | en_US |
dc.relation.journalvolume | 117 | en_US |
dc.relation.journalissue | 11 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | Dentistry-NTUHHC | - |
crisitem.author.dept | Institute of Health Data Analytics and Statistics | - |
crisitem.author.dept | Master of Public Health Degree Program | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Dentistry | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | Clinical Dentistry | - |
crisitem.author.dept | Dentistry-NTUH | - |
crisitem.author.dept | School of Dentistry | - |
crisitem.author.orcid | 0000-0001-8129-6701 | - |
crisitem.author.orcid | 0000-0002-6149-525X | - |
crisitem.author.orcid | 0000-0002-2461-474X | - |
crisitem.author.orcid | 0000-0003-4479-3391 | - |
crisitem.author.orcid | 0000-0001-8321-2575 | - |
crisitem.author.orcid | 0000-0002-9008-8346 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
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