Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. School of Medicine / 醫學系
  4. Screening and eradication of Helicobacter pylori for gastric cancer prevention: The Taipei global consensus
 
  • Details

Screening and eradication of Helicobacter pylori for gastric cancer prevention: The Taipei global consensus

Journal
Gut
Journal Volume
69
Journal Issue
12
Pages
2093-2112
Date Issued
2020
Author(s)
JYH-MING LIOU  
Malfertheiner P.
YI-CHIA LEE  
Sheu B.-S.
Sugano K.
Cheng H.-C.
Yeoh K.-G.
Hsu P.-I.
Goh K.-L.
Mahachai V.
Gotoda T.
Chang W.-L.
MEI-JYH CHEN  
TSUNG-HSIEN CHIANG  
CHIEH-CHANG CHEN  
Wu C.-Y.
Leow A.H.-R.
Wu J.-Y.
Wu D.-C.
TZU-CHAN HONG  
Lu H.
Yamaoka Y.
Megraud F.
Chan F.K.L.
Sung J.J.Y.
Lin J.-T.
Graham D.Y.
MING-SHIANG WU  
El-Omar E.M.
DOI
10.1136/gutjnl-2020-322368
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091493329&doi=10.1136%2fgutjnl-2020-322368&partnerID=40&md5=ac515e72f98d7e2e6ff15831111c71e2
https://scholars.lib.ntu.edu.tw/handle/123456789/545372
Abstract
Objective A global consensus meeting was held to review current evidence and knowledge gaps and propose collaborative studies on population-wide screening and eradication of Helicobacter pylori for prevention of gastric cancer (GC). Methods 28 experts from 11 countries reviewed the evidence and modified the statements using the Delphi method, with consensus level predefined as ?80% of agreement on each statement. The Grading of Recommendation Assessment, Development and Evaluation (GRADE) approach was followed. Results Consensus was reached in 26 statements. At an individual level, eradication of H. pylori reduces the risk of GC in asymptomatic subjects and is recommended unless there are competing considerations. In cohorts of vulnerable subjects (eg, first-degree relatives of patients with GC), a screen-and-treat strategy is also beneficial. H. pylori eradication in patients with early GC after curative endoscopic resection reduces the risk of metachronous cancer and calls for a re-examination on the hypothesis of a € the point of no return'. At the general population level, the strategy of screen-and-treat for H. pylori infection is most cost-effective in young adults in regions with a high incidence of GC and is recommended preferably before the development of atrophic gastritis and intestinal metaplasia. However, such a strategy may still be effective in people aged over 50, and may be integrated or included into national healthcare priorities, such as colorectal cancer screening programmes, to optimise the resources. Reliable locally effective regimens based on the principles of antibiotic stewardship are recommended. Subjects at higher risk of GC, such as those with advanced gastric atrophy or intestinal metaplasia, should receive surveillance endoscopy after eradication of H. pylori. Conclusion Evidence supports the proposal that eradication therapy should be offered to all individuals infected with H. pylori. Vulnerable subjects should be tested, and treated if the test is positive. Mass screening and eradication of H. pylori should be considered in populations at higher risk of GC. ? 2020 BMJ Publishing Group. All rights reserved.
SDGs

[SDGs]SDG3

Other Subjects
antibiotic agent; antiinfective agent; proton pump inhibitor; antimicrobial stewardship; asymptomatic disease; atrophic gastritis; bacterial clearance; cancer incidence; cancer prevention; cancer risk; cancer screening; colorectal cancer; consensus; cost effectiveness analysis; Delphi study; endoscopic surgery; first-degree relative; gastroscopy; Helicobacter infection; high risk patient; human; intestine metaplasia; medical expert; nonhuman; priority journal; Review; risk reduction; screening; stomach atrophy; stomach cancer; Taiwan; vulnerable population; antibiotic resistance; atrophic gastritis; clinical decision making; consensus development; cost benefit analysis; dose response; drug administration; early cancer diagnosis; gastroesophageal reflux; gastrointestinal endoscopy; genetic marker; global health; Helicobacter infection; Helicobacter pylori; intestine flora; metabolic syndrome X; metaplasia; microbiology; reinfection; stomach tumor; Anti-Bacterial Agents; Antimicrobial Stewardship; Clinical Decision-Making; Cost-Benefit Analysis; Delphi Technique; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Bacterial; Early Detection of Cancer; Endoscopy, Gastrointestinal; Gastritis, Atrophic; Gastroesophageal Reflux; Gastrointestinal Microbiome; Genetic Markers; Global Health; Helicobacter Infections; Helicobacter pylori; Humans; Metabolic Syndrome; Metaplasia; Proton Pump Inhibitors; Reinfection; Stomach Neoplasms
Publisher
BMJ Publishing Group
Type
review

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science