https://scholars.lib.ntu.edu.tw/handle/123456789/547771
DC 欄位 | 值 | 語言 |
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dc.contributor.author | SHIN-YU LIN | en_US |
dc.contributor.author | SONG-CHOU HSIEH | en_US |
dc.contributor.author | Lin, Y.-C. | en_US |
dc.contributor.author | CHIEN-NAN LEE | en_US |
dc.contributor.author | MONG-HSUN TSAI | en_US |
dc.contributor.author | LIANG-CHUAN LAI | en_US |
dc.contributor.author | ERIC YAO-YU CHUANG | en_US |
dc.contributor.author | PAU-CHUNG CHEN | en_US |
dc.contributor.author | Hung, C.-C. | en_US |
dc.contributor.author | Chen, L.-Y. | en_US |
dc.contributor.author | WU-SHIUN HSIEH | en_US |
dc.contributor.author | Niu, D.-M. | en_US |
dc.contributor.author | Su, Y.-N. | en_US |
dc.contributor.author | HONG-NERNG HO | en_US |
dc.creator | Lin S.-Y.;Hsieh S.-C.;Lin Y.-C.;Chien-Nan Lee;Tsai M.-H.;Lai L.-C.;Chuang E.Y.;Chen P.-C.;Hung C.-C.;Chen L.-Y.;Hsieh W.S.;Niu D.-M.;Su Y.-N.;Ho H.-N. | - |
dc.date.accessioned | 2021-02-04T06:04:50Z | - |
dc.date.available | 2021-02-04T06:04:50Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 14664879 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84859924136&doi=10.1038%2fgene.2011.74&partnerID=40&md5=e3b9e95d8cc0cd41c7444b2b4b413d53 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/547771 | - |
dc.description.abstract | The etiology of systemic lupus erythematosus (SLE) involves a complex interaction of genetic and environmental factors. Investigations have shown that environmentally driven epigenetic changes contribute to the etiology of SLE. Here, we hypothesize that aberrant DNA methylation may contribute to the activation of the immune machinery and trigger lupus disease activity. A whole genome methylation array was applied to investigate the DNA methylation changes between 12 pairs of active SLE patients and healthy controls. The results were further confirmed in 66 SLE patients, 102 healthy controls. The methylation statuses of the IL10 and IL1R2 genes were significantly reduced in the SLE patient samples relative to the healthy controls (age-adjusted odds ratios, 64.2 and 16.9, respectively, P<0.0001). There was a trend toward SLE patients having hypomethylated IL10 and IL1R2 genes accompanied by greater disease activity. We observed that the methylation degree of IL10 and IL1R2 genes were reduced in the rheumatoid arthritis (RA) patients as well but the hypomethylation change was more significant in IL1R2 genes than in the IL10 genes in RA patients. This study demonstrated that DNA hypomethylation might be associated with SLE. Hypomethylated IL10 and IL1R2 genes may provide potential epigenetic markers as clinical predictors for autoimmune diseases. © 2012 Macmillan Publishers Limited All rights reserved. | - |
dc.relation.ispartof | Genes and Immunity | en_US |
dc.subject | DNA hypomethylation; IL10; IL1R2; methylation array; systemic lupus erythematosus | - |
dc.subject.other | DNA; interleukin 1 receptor; interleukin 1 receptor 2; interleukin 10; unclassified drug; article; clinical article; controlled study; disease activity; DNA methylation; genome analysis; human; priority journal; rheumatoid arthritis; risk assessment; systemic lupus erythematosus; Arthritis, Rheumatoid; DNA Methylation; Epigenesis, Genetic; Gene Regulatory Networks; Genome, Human; Humans; Interleukin-10; Lupus Erythematosus, Systemic; Promoter Regions, Genetic; Receptors, Interleukin-1 Type II | - |
dc.title | A whole genome methylation analysis of systemic lupus erythematosus: Hypomethylation of the IL10 and IL1R2 promoters is associated with disease activity | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/gene.2011.74 | - |
dc.identifier.pmid | 22048455 | - |
dc.identifier.scopus | 2-s2.0-84859924136 | - |
dc.relation.pages | 214-220 | en_US |
dc.relation.journalvolume | 13 | en_US |
dc.relation.journalissue | 3 | en_US |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.dept | Obstetrics&Gynecology-NTUHHC | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.dept | Obstetrics&Gynecology-NTUHHC | - |
crisitem.author.dept | Biotechnology | - |
crisitem.author.dept | Center for Biotechnology | - |
crisitem.author.dept | Genome and Systems Biology Degree Program | - |
crisitem.author.dept | Physiology | - |
crisitem.author.dept | Electrical Engineering | - |
crisitem.author.dept | Biomedical Electronics and Bioinformatics | - |
crisitem.author.dept | Center for Biotechnology | - |
crisitem.author.dept | Genome and Systems Biology Degree Program | - |
crisitem.author.dept | Institute of Environmental and Occupational Health Sciences | - |
crisitem.author.dept | Environmental and Occupational Medicine-NTUH | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.orcid | 0000-0002-0753-2793 | - |
crisitem.author.orcid | 0000-0002-1725-0407 | - |
crisitem.author.orcid | 0000-0001-8777-5818 | - |
crisitem.author.orcid | 0000-0002-3913-5338 | - |
crisitem.author.orcid | 0000-0003-2530-0096 | - |
crisitem.author.orcid | 0000-0002-6242-5974 | - |
crisitem.author.orcid | 0000-0002-0609-3311 | - |
crisitem.author.orcid | 0000-0002-7207-0089 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | College of Bioresources and Agriculture | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | College of Electrical Engineering and Computer Science | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | College of Life Science | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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