https://scholars.lib.ntu.edu.tw/handle/123456789/548520
Title: | Cortisol awakening response in patients with bipolar disorder during acute episodes and partial remission: A pilot study | Authors: | Huang M.-C. Chuang S.-C. Tseng M.-C.M. YI-LING CHIEN Shih-Cheng Liao HSI-CHUNG CHEN HSIU-PO KUO |
Issue Date: | 2017 | Journal Volume: | 258 | Start page/Pages: | 594-597 | Source: | Psychiatry Research | Abstract: | This exploratory study examined the cortisol awakening response (CAR) in patients with bipolar disorder (BPD) at acute phases and partial remission of manic or depressive episodes. Saliva samples of twenty-seven BPD inpatients and 25 healthy controls were collected to determine the CAR patterns, and 12 patients were sampled again at partial remission. BPD patients exhibited a non-enhanced CAR pattern. Lower cortisol expression and a blunted CAR distinguished bipolar-depressive patients from the controls. The intra-individual follow-up for both patient groups revealed a non-significant improvement in CAR patterns, indicating a trend of a normalized CAR after partial remission for BPD patients. ? 2017 Elsevier B.V. |
URI: | 2-s2.0-85028974383 https://scholars.lib.ntu.edu.tw/handle/123456789/548520 |
ISSN: | 1651781 | DOI: | 10.1016/j.psychres.2017.08.084 | SDG/Keyword: | hydrocortisone; hydrocortisone; adult; aged; arousal; Article; bipolar disorder; clinical article; controlled study; cortisol awakening response; depression; disease association; exploratory research; follow up; human; mania; patient assessment; pilot study; priority journal; remission; saliva analysis; symptom; bipolar disorder; case control study; metabolism; middle aged; pathophysiology; saliva; wakefulness; Adult; Bipolar Disorder; Case-Control Studies; Depression; Humans; Hydrocortisone; Middle Aged; Pilot Projects; Saliva; Wakefulness |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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