https://scholars.lib.ntu.edu.tw/handle/123456789/548548
Title: | Cardiac vagal control and theoretical models of co-occurring depression and anxiety: A cross-sectional psychophysiological study of community elderly | Authors: | HSI-CHUNG CHEN Yang C.C.H. Kuo T.B.J. Su T.-P. Chou P. |
Keywords: | Cardiac vagal control; Co-occurring depression and anxiety; Heart rate variability; The Hospital Anxiety and Depression Scale; Tripartite model | Issue Date: | 2012 | Journal Volume: | 12 | Start page/Pages: | 93 | Source: | BMC Psychiatry | Abstract: | Background: In order to elucidate the complex relationship between co-occurring depression and anxiety with cardiac autonomic function in the elderly, this study examined the correlation between cardiac vagal control (CVC) and pre-defined, theoretical factors from the Hospital Anxiety and Depression Scale (HADS).Methods: Three hundred fifty-four randomly selected Chinese male subjects aged ?65 years and living in the community were enrolled. CVC was measured using a frequency-domain index of heart rate variability.Results: Confirmatory factor analysis showed that the flat tripartite model of HADS provided a modest advantage in model fit when compared with other theoretical factor solutions. In the flat tripartite model, there was a significant negative association between anhedonic depression and CVC. In contrast, autonomic anxiety showed a significant positive correlation with CVC. In the hierarchical tripartite model, negative affectivity was not directly associated with CVC; instead, it had positive and negative indirect effects on CVC via autonomic anxiety and anhedonic depression, respectively. As scores for negative affectivity increased, these specific indirect effects diminished.Conclusions: Among competing models of co-occurring depression and anxiety, constructs from tripartite models demonstrate fair conformity with the data but unique and distinct correlations with CVC. Negative affectivity may determine the relationship of anhedonic depression and autonomic anxiety with CVC. Separating affective symptoms under the constructs of the tripartite models helps disentangle complex associations between co-occurring depression and anxiety with CVC. ? 2012 Chen et al.; licensee BioMed Central Ltd. |
URI: | 2-s2.0-84864336273 https://scholars.lib.ntu.edu.tw/handle/123456789/548548 |
ISSN: | 1471244X | DOI: | 10.1186/1471-244X-12-93 | SDG/Keyword: | aged; anhedonia; anxiety disorder; article; cardiac vagal control; community living; cross-sectional study; depression; disease association; elderly care; heart rate variability; Hospital Anxiety and Depression Scale; human; major clinical study; male; nerve function; psychophysiology; theoretical model; tripartite model; vagus nerve stimulation; anxiety; Article; depression; factorial analysis; geriatric patient; heart function; linear regression analysis; psychophysiology; scoring system; theoretical model; vagus reflex; very elderly; Aged; Aged, 80 and over; Anxiety; Anxiety Disorders; Autonomic Nervous System; Cross-Sectional Studies; Depression; Depressive Disorder; Heart Rate; Humans; Male; Models, Theoretical |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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