https://scholars.lib.ntu.edu.tw/handle/123456789/548821
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wan-Ting Huang | en_US |
dc.contributor.author | Juan Y.-C. | en_US |
dc.contributor.author | Liu C.-H. | en_US |
dc.contributor.author | Yang Y.-Y. | en_US |
dc.contributor.author | KIN-WEI CHAN | en_US |
dc.creator | Huang W.-T.;Juan Y.-C.;Liu C.-H.;Yang Y.-Y.;Kin-Wei Chan | - |
dc.date.accessioned | 2021-02-08T07:23:45Z | - |
dc.date.available | 2021-02-08T07:23:45Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 0264-410X | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85088802752&doi=10.1016%2fj.vaccine.2020.07.038&partnerID=40&md5=b5e5c5ca9965d7e0ab9e83507bbe5ca9 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/548821 | - |
dc.description.abstract | Background: Since 2006, two rotavirus vaccines have been licensed in Taiwan, either as a 2- (RV1) or 3-dose (RV5) schedule administered at ages 2, 4, and 6 months. This study assessed the risk of intussusception and Kawasaki disease (KD) associated with rotavirus vaccines among infants. Methods: Cases of intussusception and KD in infants aged less than 365 days were identified from the National Health Insurance databases, from 1 January 2007 through 31 December 2014, using the first-ever ICD-9-CM diagnosis codes. Histories of rotavirus vaccination were obtained from the National Immunization Information System. The modified self-controlled case series design included vaccinated cases, and compared incidence rate ratios (IRRs) between the risk period (postvaccination days 1–21 [intussusception] or days 1–28 [KD]) and control period (ages 0–364 days outside the ?14 to +21 [intussusception] or +28 [KD] days of vaccination) by each type and dose of vaccine. Conditional Poisson regression models were adjusted for age using age-in-week (7-day) categorization. Results: Overall 2064 intussusception cases and 2079 KD cases were diagnosed in 567,726 recipients (5313 [0.9%] received both RV5 and RV1). An increase in intussusception risk was observed in the 1–7 days (IRR 12.59, 95% confidence interval [CI] 8.07–19.66) and 8–21 days (IRR 1.78, 95% CI 1.00–3.16) post dose 1 of RV1, but not RV5. Risk of KD was higher during the third week post dose 2 of RV5 (IRR 2.33, 95% CI 1.35–4.00), and fourth week post dose 1 of RV1 (IRR 1.98, 95% CI 1.16–3.40). Conclusion: Our finding of an increased risk of intussusception associated with RV1 in the first week after dose 1 is consistent with results of previous postlicensure studies. Further research should verify a potentially delayed risk of KD after rotavirus vaccination. ? 2020 Elsevier Ltd | en_US |
dc.publisher | Elsevier Ltd | en_US |
dc.relation.ispartof | Vaccine | en_US |
dc.subject | Intussusception; Kawasaki disease; Rotavirus vaccine; Self-controlled design; Taiwan | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Rotavirus vaccine; live vaccine; Rotavirus vaccine; age; Article; case study; controlled study; disease registry; disease risk assessment; drug dosage form comparison; female; human; ICD-9-CM; incidence; infant; intussusception; major clinical study; male; medical history; medical information system; mucocutaneous lymph node syndrome; newborn; patient identification; priority journal; regression analysis; Rotavirus infection; rotavirus vaccination; Taiwanese; vaccination; aged; child; complication; intussusception; mucocutaneous lymph node syndrome; preschool child; Rotavirus; Rotavirus infection; Taiwan; vaccination; Aged; Child; Child, Preschool; Humans; Infant; Intussusception; Mucocutaneous Lymph Node Syndrome; Rotavirus; Rotavirus Infections; Rotavirus Vaccines; Taiwan; Vaccination; Vaccines, Attenuated | - |
dc.title | Intussusception and Kawasaki disease after rotavirus vaccination in Taiwanese infants | en_US |
dc.type | journal article | en_US |
dc.identifier.doi | 10.1016/j.vaccine.2020.07.038 | - |
dc.identifier.pmid | 32736940 | - |
dc.identifier.scopus | 2-s2.0-85088802752 | - |
dc.relation.pages | 6299-6303 | en_US |
dc.relation.journalvolume | 38 | en_US |
dc.relation.journalissue | 40 | en_US |
item.openairetype | journal article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Global Health Program | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.orcid | 0000-0002-4344-9567 | - |
crisitem.author.orcid | 0000-0001-8161-1986 | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
Appears in Collections: | 腫瘤醫學研究所 |
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