https://scholars.lib.ntu.edu.tw/handle/123456789/549398
標題: | Extended-field bone marrow sparing radiotherapy for primary chemoradiotherapy in cervical cancer patients with para-aortic lymphadenopathy: Volumetric-modulated arc therapy versus helical tomotherapy | 作者: | JENNY LING-YU CHEN Wang M.-C. YU-SEN HUANG CHAO YUAN HUANG Pan C.-K. CHE-YU HSU KENG-HSUEH LAN SUNG-HSIN KUO |
公開日期: | 2020 | 出版社: | IOS Press | 卷: | 28 | 期: | 1 | 起(迄)頁: | 111-124 | 來源出版物: | Journal of X-Ray Science and Technology | 摘要: | BACKGROUND: Extended-field (EF) bone marrow-sparing (BMS) radiotherapy is attracting interest for cervical cancer patients with para-aortic lymphadenopathy. OBJECTIVE: To compare dosimetric quality of volumetric-modulated arc therapy (VMAT) vs. helical tomotherapy (HT) during EF BMS radiotherapy. METHODS: HT dose-volume histogram parameters including (1) coverage, homogeneity, and conformity of target volumes, (2) sparing of organs-at-risk, (3) monitor units, and (4) estimated treatment time were compared with those of VMAT in 20 cervical cancer patients who underwent EF BMS radiotherapy. The pelvic and para-aortic regions received 45-Gy dose (25 fractions), with simultaneous integrated boost of 55Gy (25 fractions) for pelvic and para-aortic lymphadenopathy, followed by a parametrial boost of 9Gy (5 fractions). RESULTS: The HT-based and VMAT techniques achieved adequate and similar target volume coverage with good dose homogeneity and conformity, while sparing all organs-at-risk, including the rectum, bladder, bowel, bone marrow, femoral head, kidney, and spinal cord. The HT treatment plan had significantly higher monitor units (p<0.001) and longer estimated treatment times (p<0.001). CONCLUSIONS: VMAT and HT plans are suitable for EF BMS radiotherapy, which can achieve adequate target volume coverage while sufficiently sparing normal tissue. In addition, VMAT, compared to HT planning, yielded shorter estimated treatment times. ? 2020-IOS Press and the authors. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080853262&doi=10.3233%2fXST-190593&partnerID=40&md5=6c1daf0cd11aca6b87d42d22a6f4888c https://scholars.lib.ntu.edu.tw/handle/123456789/549398 |
ISSN: | 0895-3996 | DOI: | 10.3233/XST-190593 | SDG/關鍵字: | Blood vessels; Diseases; Risk perception; Bone marrow; Cervical cancers; Dose-volume histograms; Extended fields; Helical tomotherapy; Simultaneous integrated boosts; Treatment plans; Volumetric modulated arc therapy; Radiotherapy; adult; aged; bone marrow; chemoradiotherapy; comparative study; complication; diagnostic imaging; female; human; intensity modulated radiation therapy; lymphadenopathy; middle aged; organs at risk; procedures; radiotherapy planning system; uterine cervix tumor; x-ray computed tomography; Adult; Aged; Bone Marrow; Chemoradiotherapy; Female; Humans; Lymphadenopathy; Middle Aged; Organs at Risk; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Intensity-Modulated; Tomography, X-Ray Computed; Uterine Cervical Neoplasms |
顯示於: | 腫瘤醫學研究所 |
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