https://scholars.lib.ntu.edu.tw/handle/123456789/550194
Title: | Psychometric assessment of female overactive bladder syndrome and antimuscarinics-related effects | Authors: | Hsiao S.-M. SHIH-CHENG LIAO CHI-HAU CHEN TING-CHEN CHANG HO-HSIUNG LIN |
Issue Date: | 2014 | Publisher: | Elsevier Ireland Ltd | Journal Volume: | 79 | Journal Issue: | 4 | Start page/Pages: | 428-434 | Source: | Maturitas | Abstract: | Objectives To investigate the characteristics of psychological distress (PD), personality traits, and family support in women with overactive bladder syndrome (OAB), and the effects of antimuscarinic treatment.Study design Women with and without OAB (age- and body mass index [BMI]-matched control group) were prospectively enrolled; they recorded bladder diaries, underwent urodynamic studies, and completed PD, personality traits, and filled family support questionnaires before and after antimuscarinic treatment. OAB women underwent treatment with tolterodine or solifenacin for 12 weeks. The control group completed questionnaires.Main outcome measures The differences in PD, personality traits, and family support scores between both groups, and the changes after antimuscarinic treatment in OAB women.Results Eighty-five women with OAB (tolterodine, n = 42; solifenacin, n = 43) and 65 without OAB completed the studies. Linear regression analysis with age and BMI adjustment revealed: coefficients of OAB were significant (all P < 0.05) for somatic complaints (mean: 0.87 vs. 0.63, coefficient = 0.21), obsessive-compulsive symptoms (0.69 vs. 0.44, coefficient = 0.25), anxiety symptoms (0.42 vs. 0.27, coefficient = 0.14), General Symptom Index (GSI, 0.48 vs. 0.33, coefficient = 0.14), neuroticism (9.23 vs. 5.17, coefficient = 3.73), and extroversion-introversion (13.64 vs. 15.25, coefficient = -1.73). Anxiety symptoms (0.42 vs. 0.36) and GSI (0.48 vs. 0.39) improved after antimuscarinics (all P < 0.05). High Overactive Bladder Symptom Score questionnaire score (coefficient = -0.39), low hostility score (coefficient = 2.11), and high additional symptoms score (coefficient = -1.46) were associated with good therapeutic effect (all P < 0.05).Conclusions OAB women experience more PD, neuroticism, and introversion than asymptomatic women, and antimuscarinics could improve PD. ? 2014 Elsevier Ireland Ltd. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84918827760&doi=10.1016%2fj.maturitas.2014.08.009&partnerID=40&md5=c29c3ed5903ab17b480ebf97a4160a31 https://scholars.lib.ntu.edu.tw/handle/123456789/550194 |
ISSN: | 0378-5122 | DOI: | 10.1016/j.maturitas.2014.08.009 | SDG/Keyword: | solifenacin; tolterodine; muscarinic receptor blocking agent; solifenacin; tolterodine; adult; amnesia; anxiety; Article; body mass; clinical trial; cognitive defect; confusion; controlled study; depression; distress syndrome; dizziness; drug effect; drug efficacy; drug induced headache; drug withdrawal; extraversion; female; follow up; general symptom index; high overreactive bladder symptom questionnaire score; human; introversion; low hostility score; major clinical study; named inventories, questionnaires and rating scales; obsessive compulsive disorder; open study; overactive bladder; paranoia; phobia; prospective study; psychometry; somnolence; therapy effect; treatment duration; middle aged; psychology; psychometry; quality of life; questionnaire; statistical model; Urinary Bladder, Overactive; women's health; Female; Humans; Linear Models; Middle Aged; Muscarinic Antagonists; Psychometrics; Quality of Life; Solifenacin Succinate; Surveys and Questionnaires; Tolterodine Tartrate; Urinary Bladder, Overactive; Women's Health |
Appears in Collections: | 醫學系 |
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