https://scholars.lib.ntu.edu.tw/handle/123456789/551068
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Hu K.-C. | en_US |
dc.contributor.author | MING-SHIANG WU | en_US |
dc.contributor.author | Chu C.-H. | en_US |
dc.contributor.author | Wang H.-Y. | en_US |
dc.contributor.author | Lin S.-C. | en_US |
dc.contributor.author | Liu C.-C. | en_US |
dc.contributor.author | TUNG-HUNG SU | en_US |
dc.contributor.author | WEI-CHIH LIAO | en_US |
dc.contributor.author | CHI-LING CHEN | en_US |
dc.contributor.author | CHUN-JEN LIU | en_US |
dc.contributor.author | Shih S.-C. | en_US |
dc.date.accessioned | 2021-03-09T01:43:18Z | - |
dc.date.available | 2021-03-09T01:43:18Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1058-4838 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85067274004&doi=10.1093%2fcid%2fciy591&partnerID=40&md5=8e9702a227b649efb6b6aa7c45d31292 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/551068 | - |
dc.description.abstract | Background: Helicobacter pylori infection is associated with colorectal adenoma and confers a 1.3- to 2.26-fold increased risk. We evaluated the association between H. pylori and the progression of colorectal adenoma. Methods: This retrospective cohort study included 615 adults with no history of colorectal adenoma or cancer at baseline who participated in a repeated, regular health screening examination, which included a bidirectional gastrointestinal endoscopy, between July 2006 and June 2015. A gastric biopsy specimen from each subject was tested for H. pylori. Results: During follow-up, the incidence rates of colorectal adenoma progression in participants with persistent H. pylori infections (persistent group) and those whose infections had previously been successfully eradicated (eradication group) were 160.52 and 51.60 per 1000 person-years, respectively (P =. 0003). After adjustment for confounding factors, the persistent group exhibited a higher risk of colorectal adenoma than the eradication group (hazard ratio = 3.04, 95% CI 1.899, 5.864). The colorectal adenoma ratio of patients uninfected with H. pylori was similar to that of the eradication group (23.93% vs 20.12%, P =. 328). Conclusions: Persistent H. pylori infection was associated significantly with the independent development of colorectal adenoma. H. pylori infection may have a pathophysiological role in colorectal adenoma development and, after successful eradication of H. pylori, the colorectal adenoma ratio might decrease. ? 2018 The Author(s) 2018. | - |
dc.publisher | Oxford University Press | - |
dc.relation.ispartof | Clinical Infectious Diseases | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | adenoma; adult; aged; colorectal tumor; complication; female; health survey; Helicobacter infection; Helicobacter pylori; human; incidence; Kaplan Meier method; male; microbiology; middle aged; proportional hazards model; retrospective study; risk assessment; risk factor; socioeconomics; Adenoma; Adult; Aged; Colorectal Neoplasms; Female; Helicobacter Infections; Helicobacter pylori; Humans; Incidence; Kaplan-Meier Estimate; Male; Middle Aged; Proportional Hazards Models; Public Health Surveillance; Retrospective Studies; Risk Assessment; Risk Factors; Socioeconomic Factors | - |
dc.title | Decreased Colorectal Adenoma Risk after Helicobacter pylori Eradication: A Retrospective Cohort Study | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1093/cid/ciy591 | - |
dc.identifier.pmid | 30566695 | - |
dc.identifier.scopus | 2-s2.0-85067274004 | - |
dc.relation.pages | 2105-2113 | - |
dc.relation.journalvolume | 68 | - |
dc.relation.journalissue | 12 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Integrated Diagnostics and Therapeutics-NTUH | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-1940-6428 | - |
crisitem.author.orcid | 0000-0002-6747-7941 | - |
crisitem.author.orcid | 0000-0001-5362-6953 | - |
crisitem.author.orcid | 0000-0002-6202-0993 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
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