|Title:||Overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM||Authors:||Yen I.-W.
|Issue Date:||2019||Publisher:||Public Library of Science||Journal Volume:||14||Journal Issue:||12||Start page/Pages:||e0225978||Source:||PLoS ONE||Abstract:||
Aim Overweight and obesity are important risk factors of gestational diabetes mellitus (GDM). Clustering of metabolic risk factors in early pregnancy may be a potential pathogenesis between the link of overweight/obesity and GDM. Since it remains unexplored, we investigated if overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM in this cohort study. Methods Total 527 women who visited National Taiwan University Hospital for prenatal care in between November 2013 to April 2018 were enrolled. Risk factors of GDM in the first prenatal visit (FPV) were recorded. Overweight/obesity was defined if body mass index ?24 kg/ m2. GDM was diagnosed from the result of a 75g oral glucose tolerance test in 24–28 gestational weeks. Results Overweight/obesity was associated with clustering of metabolic risk factors of GDM, including high fasting plasma glucose, high HbA1c, insulin resistance, high plasma triglyceride and elevated blood pressure in FPV (p<0.05). There was a positive relationship between the number of metabolic risk factors and the incidence of GDM (p <0.05). The odds ratios of HbA1c and diastolic blood pressure were higher in overweight/obese women, compared with those in normal-weight women. ? 2019 Yen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
|ISSN:||1932-6203||DOI:||10.1371/journal.pone.0225978||metadata.dc.subject.other:||glucose; hemoglobin A1c; triacylglycerol; biological marker; adult; Article; blood pressure; body mass; cohort analysis; controlled study; diastolic blood pressure; female; first trimester pregnancy; glucose blood level; human; insulin resistance; major clinical study; morbidity; obesity; oral glucose tolerance test; pathogenesis; pregnancy diabetes mellitus; prenatal care; prospective study; risk factor; Taiwan; triacylglycerol blood level; university hospital; complication; disease predisposition; energy metabolism; gestational age; metabolism; obesity; pregnancy; pregnancy diabetes mellitus; risk assessment; young adult; Adult; Biomarkers; Diabetes, Gestational; Disease Susceptibility; Energy Metabolism; Female; Gestational Age; Humans; Obesity; Overweight; Pregnancy; Risk Assessment; Risk Factors; Young Adult
|Appears in Collections:||醫學系|
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