https://scholars.lib.ntu.edu.tw/handle/123456789/551511
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | WERN-CHERNG CHENG | en_US |
dc.contributor.author | MEN-LUH YEN | en_US |
dc.contributor.author | SANDY HUEY-JEN HSU | en_US |
dc.contributor.author | Chen K.-H. | en_US |
dc.contributor.author | KEH-SUNG TSAI | en_US |
dc.creator | Cheng W.-C.;Yen M.-L.;Hsu S.H.J.;Chen K.-H.;Keh-Sung Tsai | - |
dc.date.accessioned | 2021-03-10T08:56:04Z | - |
dc.date.available | 2021-03-10T08:56:04Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 1355-008X | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/551511 | - |
dc.description.abstract | To investigate the clinical effects of raloxifene, one of the selective estrogen receptor modulators (SERMs), on the pituitary-ovary axis and prolactin, a prospective, randomized, double-blinded study on 59 healthy postmenopausal women was performed. Forty-eight women received raloxifene 60 mg daily. The other 11 received combined conjugated equine estrogen 0.625 mg and medroxyprogesterone acetate 5 mg daily (CCEP) as active controls. Serum follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and prolactin were measured at baseline and 1 yr after treatment. The mean levels of FSH and LH were significantiy decreased in the raloxifene group (FSH: -10.7%; p < 0.01, LH: -10.3%; p < 0.05) and CCEP group (FSH: -53.7%, p < 0.001; LH: -46.8%, p < 0.001). The prolactin level decreased in the raloxifene group but not in the CCEP group (-17.0%; p < 0.001 vs +13.3%, p = no significance; NS). Consequently, long-term administration of raloxifene up to 1 yr decreases serum prolactin level significantly and may be a therapeutic alternative for postmenopausal osteoporotic women with hyperprolactinemia. | - |
dc.relation.ispartof | Endocrine | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | conjugated estrogen; estradiol; follitropin; luteinizing hormone; medroxyprogesterone; prolactin; raloxifene; selective estrogen receptor modulator; conjugated estrogen; estradiol; follitropin; luteinizing hormone; medroxyprogesterone acetate; prolactin; raloxifene; selective estrogen receptor modulator; adult; article; clinical trial; controlled clinical trial; controlled study; double blind procedure; drug effect; dyspepsia; female; flatulence; follitropin blood level; headache; human; hyperprolactinemia; hypophysis; luteinizing hormone blood level; normal human; osteoporosis; ovary; postmenopause; priority journal; prolactin blood level; randomized controlled trial; spotting; statistical significance; blood; drug antagonism; middle aged; oral drug administration; Administration, Oral; Double-Blind Method; Estradiol; Estrogens, Conjugated (USP); Female; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; Medroxyprogesterone 17-Acetate; Middle Aged; Ovary; Pituitary Gland; Postmenopause; Prolactin; Raloxifene; Selective Estrogen Receptor Modulators | - |
dc.title | Effects of raloxifene, one of the selective estrogen receptor modulators, on pituitary-ovary axis and prolactin in postmenopausal women | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1385/ENDO:23:2-3:215 | - |
dc.identifier.pmid | 15146102 | - |
dc.identifier.scopus | 2-s2.0-4243079985 | - |
dc.relation.pages | 215-218 | - |
dc.relation.journalvolume | 23 | - |
dc.relation.journalissue | 2-3 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.orcid | 0000-0002-5536-5942 | - |
crisitem.author.orcid | 0000-0003-3800-3664 | - |
crisitem.author.orcid | 0000-0002-5539-4858 | - |
crisitem.author.orcid | 0000-0001-8528-1566 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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