https://scholars.lib.ntu.edu.tw/handle/123456789/551596
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | YEN-WEN WU | en_US |
dc.contributor.author | Ho, Sing Kong | en_US |
dc.contributor.author | Tseng, Wei-Kung | en_US |
dc.contributor.author | Yeh, Hung-I | en_US |
dc.contributor.author | Leu, Hsin-Bang | en_US |
dc.contributor.author | Yin, Wei-Hsian | en_US |
dc.contributor.author | Lin, Tsung-Hsien | en_US |
dc.contributor.author | Chang, Kuan-Cheng | en_US |
dc.contributor.author | Wang, Ji-Hung | en_US |
dc.contributor.author | CHAU-CHUNG WU | en_US |
dc.contributor.author | Chen, Jaw-Wen | en_US |
dc.date.accessioned | 2021-03-11T02:12:16Z | - |
dc.date.available | 2021-03-11T02:12:16Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/551596 | - |
dc.description.abstract | This study aimed to investigate the prognostic value of high-sensitivity creatine kinase-myocardial band or fraction (hsCK-MB) in comparison with other well-established biomarkers including heart type-fatty acid binding protein (H-FABP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with stable coronary heart disease (SCHD). A total of 1,785 patients were enrolled and followed for 36 months. The primary outcome was all-cause mortality. The secondary outcomes included cardiovascular (CV) death, acute myocardial infarction (AMI), angina-related hospitalizations, and hospitalizations for heart failure. The all-cause mortality rate was significantly higher in the high hsCK-MB group compared to the low hsCK-MB group (4.64% vs. 1.88%, p = 0.0026). After adjusting for baseline covariates, there were no significant differences for the secondary outcomes. H-FABP (≥4.226 ng/mL) was the best predictor for all-cause mortality (HR = 2.68, 95% CI = 1.28-5.62, p = 0.009) and CV death (HR = 6.84, 95% CI = 1.89-22.14, p = 0.003). The high NT-proBNP group had a higher AMI-related hospitalization rate (HR = 1.91, 95% CI = 1.00-3.65, p = 0.05). Neither the addition of hsCK-MB to any other markers nor combinations of the three markers improved the prognostic significance of CV outcomes. In conclusion, hsCK-MB was an independent predictor for all-cause mortality but not CV outcomes in patients with SCHD. Combination of hsCK-MB, H-FABP and NT-proBNP failed to improve the prognostic power for all-cause mortality or CV outcomes. | en_US |
dc.language.iso | animation | en_US |
dc.publisher | NATURE PUBLISHING GROUP | en_US |
dc.relation.ispartof | Scientific reports | en_US |
dc.subject | BAND ISOENZYME ELEVATION; CK-MB; TROPONIN-I; PROGNOSTIC VALUE; MORTALITY; EVENTS | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | biological marker; creatine kinase MB; fatty acid binding protein; adult; coronary artery disease; female; follow up; heart failure; heart infarction; hospitalization; human; male; metabolism; mortality; prognosis; Adult; Biomarkers; Coronary Disease; Creatine Kinase, MB Form; Fatty Acid-Binding Proteins; Female; Follow-Up Studies; Heart Failure; Hospitalization; Humans; Male; Myocardial Infarction; Prognosis | - |
dc.title | Potential impacts of high-sensitivity creatine kinase-MB on long-term clinical outcomes in patients with stable coronary heart disease | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/s41598-020-61894-3 | - |
dc.identifier.pmid | 32221337 | - |
dc.identifier.scopus | 2-s2.0-85082539163 | - |
dc.identifier.isi | WOS:000560408800017 | - |
dc.identifier.url | https://scholars.lib.ntu.edu.tw/handle/123456789/516256 | - |
dc.identifier.url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082539163&doi=10.1038%2fs41598-020-61894-3&partnerID=40&md5=8024a3844b1c3d705406d6c7103b1c06 | - |
dc.relation.journalvolume | 10 | en_US |
dc.relation.journalissue | 1 | en_US |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.languageiso639-1 | animation | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Nuclear Medicine-NTUH | - |
crisitem.author.dept | Medical Education and Bioethics | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-1520-1166 | - |
crisitem.author.orcid | 0000-0001-8191-475X | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學教育暨生醫倫理學科所 |
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