https://scholars.lib.ntu.edu.tw/handle/123456789/551675
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wu S.-J. | en_US |
dc.contributor.author | Chuang L.-Y. | en_US |
dc.contributor.author | Lin Y.-D. | en_US |
dc.contributor.author | Ho W.-H. | en_US |
dc.contributor.author | FU-TIEN CHIANG | en_US |
dc.contributor.author | Yang C.-H. | en_US |
dc.contributor.author | Chang H.-W. | en_US |
dc.creator | Wu S.-J.;Chuang L.-Y.;Lin Y.-D.;Ho W.-H.;Fu-Tien Chiang;Yang C.-H.;Chang H.-W. | - |
dc.date.accessioned | 2021-03-11T04:29:43Z | - |
dc.date.available | 2021-03-11T04:29:43Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0301-4851 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/551675 | - |
dc.description.abstract | Most non-significant individual single nucleotide polymorphisms (SNPs) were undiscovered in hypertension association studies. Their possible SNP-SNP interactions were usually ignored and leaded to missing heritability. In present study, we proposed a particle swarm optimization (PSO) algorithm to analyze the SNP-SNP interaction associated with hypertension. Genotype dataset of eight SNPs of renin-angiotensin system genes for 130 non-hypertension and 313 hypertension subjects were included. Without SNP-SNP interaction, most individual SNPs were non-significant difference between the hypertension and non-hypertension groups. For SNP-SNP interaction, PSO can select the SNP combinations involving different SNP numbers, namely the best SNP barcodes, to show the maximum frequency difference between non-hypertension and hypertension groups. After computation, the best PSO-generated SNP barcodes were dominant in non-hypertension in terms of the occurrences of frequency differences between non-hypertension and hypertension groups. The OR values of the best SNP barcodes involving 2-8 SNPs were 0.705-0.334, suggesting that these SNP barcodes were protective against hypertension. In conclusion, this study demonstrated that non-significant SNPs may generate the joint effect in association study. Our proposed PSO algorithm is effective to identify the best protective SNP barcodes against hypertension. ? 2013 Springer Science+Business Media Dordrecht. | - |
dc.relation.ispartof | Molecular Biology Reports | - |
dc.subject | Hypertension; Particle swarm optimization; Renin-angiotensin system; Single nucleotide polymorphism; SNP interactions | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | article; controlled study; DNA barcoding; gene; gene frequency; gene interaction; genetic algorithm; genetic association; genetic database; genetic screening; genotype; human; hypertension; major clinical study; particle swarm optimization algorithm; prediction; renin angiotensin aldosterone system; renin angiotensin system gene; single nucleotide polymorphism; algorithm; biological model; biology; epistasis; genetic predisposition; genetics; hypertension; procedures; reproducibility; risk; Algorithms; Computational Biology; Epistasis, Genetic; Genetic Predisposition to Disease; Genotype; Humans; Hypertension; Models, Biological; Odds Ratio; Polymorphism, Single Nucleotide; Renin-Angiotensin System; Reproducibility of Results | - |
dc.title | Particle swarm optimization algorithm for analyzing SNP-SNP interaction of renin-angiotensin system genes against hypertension | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1007/s11033-013-2504-8 | - |
dc.identifier.pmid | 23695493 | - |
dc.identifier.scopus | 2-s2.0-84879410170 | - |
dc.relation.pages | 4227-4233 | - |
dc.relation.journalvolume | 40 | - |
dc.relation.journalissue | 7 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-4936-8968 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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