https://scholars.lib.ntu.edu.tw/handle/123456789/551762
Title: | The effects of metabolic syndrome versus infectious burden on inflammation, severity of coronary atherosclerosis, and major adverse cardiovascular events | Authors: | Dai D.-F. JOU-WEI LIN JIA-HORNG KAO Hsu C.-N. FU-TIEN CHIANG JIUNN-LEE LIN Chou Y.-H. Hsu K.-L. Tseng C.-D. Tseng Y.-Z. HWANG, JUEY-JEN |
Issue Date: | 2007 | Journal Volume: | 92 | Journal Issue: | 7 | Start page/Pages: | 2532-2537 | Source: | Journal of Clinical Endocrinology and Metabolism | Abstract: | Background: The clinical predictors of inflammation in atherosclerosis remain controversial. The objective of this study was to compare the associations of metabolic factors vs. infectious burden (IB) with inflammation, the severity of coronary atherosclerosis, and major adverse cardiovascular events (MACEs). Design, Setting, and Patients: Coronary angiography with Gensini score was applied to assess the severity of coronary atherosclerosis in 568 patients with coronary artery disease. Metabolic syndrome (MS) score (0-5) was defined according to the modified criteria of National Cholesterol Education Program Adult Treatment Panel III. IB score (0-7) was defined as the number of seropositivities to several agents. Results: IB score was not associated with plasma C-reactive protein (CRP) concentration, Gensini score, or the risk of MACE. In contrast, MS score significantly correlated with both plasma CRP concentration and Gensini score (P < 0.001 for both). MS score and plasma CRP concentration were also significantly associated with the risk of MACE (hazard ratios 1.51, P < 0.001; and 1.90, P = 0.002, respectively). Conclusion: Compared with IB, metabolic abnormalities have a more prominent association with the degree of inflammation, the severity of coronary atherosclerosis, and the risk of MACE in patients with coronary artery disease. Copyright ? 2007 by The Endocrine Society. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/551762 | ISSN: | 0021-972X | DOI: | 10.1210/jc.2006-2428 | SDG/Keyword: | C reactive protein; adult; aged; angiocardiography; article; cardiovascular disease; comparative study; controlled study; coronary artery atherosclerosis; coronary artery disease; disease association; disease severity; female; hazard ratio; human; infection; inflammation; major clinical study; male; metabolic syndrome X; priority journal; protein blood level; risk assessment; scoring system; statistical significance |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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