https://scholars.lib.ntu.edu.tw/handle/123456789/551851
標題: | Effects of doxazosin on the serum lipid and coronary risk score in Chinese patients with mild to moderate hypertension | 作者: | Tseng C.-D. Tseng Y.-Z. FU-TIEN CHIANG Hsu K.-L. Lo H.-M. Wu T.-L. |
關鍵字: | coronary risk score; doxazosin; hypertension; lipid | 公開日期: | 1993 | 卷: | 9 | 期: | 4 | 起(迄)頁: | 248-253 | 來源出版物: | Acta Cardiologica Sinica | 摘要: | Doxazosin, a long-acting selective α1-adrenoceptor inhibitor, was assessed for its antihypertensive efficacy, safety and effect on lipid parameters and coronary risk score in 20 Chinese patients with essential hypertension. They were 7 males and 13 females, aged from 32 to 67 (mean 51.0) years. The study involved a 2-week baseline period, and a 10-week active treatment period in which patients received doxazosin 1 to 8 mg once daily. The mean sitting blood pressure was significantly reduced (P < 0.0001) by 18.8/13.3 mmHg at final visit with a mean dose of 3.6 mg once daily. Four patients (20%) reported side effects including dizziness in four, headache in two and insomnia in one, but symptoms were transient and not severe. No patient required dose reduction or discontinuation of therapy because of side effects. Triglyceride level was significantly reduced (P < 0.05). Total cholesterol levels showed a decreasing trend and high density lipoprotein cholesterol (HDL-C) levels showed an increasing trend, but without statistical significance (P > 0.05). From baseline to final visit, there was a highly significant, 49% (P < 0.005) reduction in calculated coronary heart disease risk score, on the basis used in the Framingham study. It was concluded that doxazosin once daily is an effective and safe regimen for Chinese patients with mild to moderate hypertension. It might also be beneficial for reducing coronary risk in these patients. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/551851 | ISSN: | 1011-6842 | SDG/關鍵字: | doxazosin; endogenous compound; adult; aged; article; clinical article; female; headache; human; hypertension; insomnia; ischemic heart disease; lipid blood level; male; oral drug administration; vertigo |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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